来伐替尼联合抗PD-1抗体加GEMOX化疗作为晚期胆囊癌非一线系统疗法的有效性和安全性。

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Yang Tan, Kai Liu, Chengpei Zhu, Shanshan Wang, Yunchao Wang, Jingnan Xue, Cong Ning, Nan Zhang, Jiashuo Chao, Longhao Zhang, Junyu Long, Xiaobo Yang, Daobing Zeng, Lijin Zhao, Haitao Zhao
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引用次数: 0

摘要

背景:伦伐替尼、程序性细胞死亡1(PD-1)抗体以及吉西他滨和奥沙利铂(GEMOX)化疗作为胆道癌的一线疗法已显示出显著的抗肿瘤活性。本研究评估了它们作为晚期胆囊癌(GBC)非一线疗法的有效性和安全性:回顾性分析了接受来伐替尼联合抗PD-1抗体和GEMOX化疗作为非一线疗法的晚期胆囊癌患者。主要终点是总生存期(OS)和无进展生存期(PFS),次要终点是客观反应率(ORR)和安全性:本研究共纳入了36名晚期GBC患者。中位随访时间为11.53个月(95%置信区间(CI):2.2-20.9),ORR为36.1%。中位OS和PFS分别为15.1个月(95% 置信区间:3.2-26.9)和6.1个月(95% 置信区间:4.9-7.2)。疾病控制率(DCR)和临床获益率(CBR)分别为75%和61.1%。亚组分析显示,有程序性细胞死亡配体1(PD-L1)表达的患者的PFS和OS明显长于无PD-L1表达的患者。此外,中性粒细胞-淋巴细胞比值(NLR)结论也表明,PD-L1表达的患者的PFS和OS明显长于无PD-L1表达的患者:抗PD-1抗体联合来伐替尼和GEMOX化疗作为晚期GBC的非一线疗法有效且耐受性良好。PD-L1 表达和基线 NLR 有可能预测疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer.

Background: Lenvatinib, programmed cell death 1 (PD-1) antibodies, and gemcitabine and oxaliplatin (GEMOX) chemotherapy have shown significant antitumor activity as first-line therapy against biliary tract cancer. This study evaluated their efficacy and safety as non-first-line therapy in advanced gallbladder cancer (GBC).

Methods: Patients with advanced GBC who received lenvatinib combined with anti-PD-1 antibodies and GEMOX chemotherapy as a non-first-line therapy were retrospectively analyzed. The primary endpoints were overall survival (OS) and progression-free survival (PFS), and the secondary endpoints were objective response rate (ORR) and safety.

Results: A total of 36 patients with advanced GBC were included in this study. The median follow-up time was 11.53 (95% confidence interval (CI): 2.2-20.9) months, and the ORR was 36.1%. The median OS and PFS were 15.1 (95% CI: 3.2-26.9) and 6.1 (95% CI: 4.9-7.2) months, respectively. The disease control rate (DCR) and clinical benefit rate (CBR) were 75% and 61.1%, respectively. Subgroup analysis demonstrated that patients with programmed cell death-ligand 1 (PD-L1) expression had significantly longer PFS and OS than those without PD-L1 expression. Additionally, patients with a neutrophil-lymphocyte ratio (NLR) < 5.57 had a longer OS than those with an NLR ≥ 5.57. All patients experienced adverse events (AEs), with 61.1% experiencing grade 3 or 4 AEs, including myelosuppression (13.9%) and fatigue (13.3%), alanine transaminase or aspartate transaminase levels (8.3%), and diarrhea (8.3%). No grade 5 AEs were reported.

Conclusion: Anti-PD-1 antibodies combined with lenvatinib and GEMOX chemotherapy are effective and well-tolerated as a non-first-line therapy in advanced GBC. PD-L1 expression and baseline NLR may potentially predict treatment efficacy.

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来源期刊
CiteScore
10.50
自引率
1.70%
发文量
207
审稿时长
1 months
期刊介绍: Cancer Immunology, Immunotherapy has the basic aim of keeping readers informed of the latest research results in the fields of oncology and immunology. As knowledge expands, the scope of the journal has broadened to include more of the progress being made in the areas of biology concerned with biological response modifiers. This helps keep readers up to date on the latest advances in our understanding of tumor-host interactions. The journal publishes short editorials including "position papers," general reviews, original articles, and short communications, providing a forum for the most current experimental and clinical advances in tumor immunology.
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