口服褪黑素对减轻儿科患者静脉穿刺时疼痛和焦虑的影响:一项双盲随机临床试验。

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Annals of Medicine and Surgery Pub Date : 2024-09-10 eCollection Date: 2024-10-01 DOI:10.1097/MS9.0000000000002163
Sara Rahafard, Zohre Akbari Jokar, Seyed Ahmad Hosseini, Ehsan Alaee
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引用次数: 0

摘要

背景:治疗过程和注射导致的疼痛是儿童普遍存在的压力来源。婴儿疼痛的直接副作用包括晕厥、烦躁、睡眠障碍和营养问题。本研究旨在探讨口服褪黑素对缓解接受静脉穿刺的儿科患者的疼痛和焦虑的影响:这项双盲随机对照试验在儿科急诊病房进行。患者被随机分配到两组中的一组;干预组在静脉穿刺前 30 分钟口服 0.5 毫克/千克褪黑素(最多 5 毫克),安慰剂组在手术前 30 分钟口服等量的安慰剂。使用脸部、腿部、活动、哭泣、安慰(FLACC)量表,对抽血后的恐惧感、疼痛严重程度、依从性和潜在副作用进行了评估:干预组和对照组共 202 名患者(男性 113 名,女性 89 名)参与了分析。干预组静脉穿刺时的平均疼痛评分为(1.52±3.04)分,对照组为(2.04±6.57)分(PPPP=0.257):结论:静脉穿刺前 30 分钟口服 0.5 毫克/千克褪黑素可减轻儿科患者与手术相关的疼痛和焦虑,并可提高静脉穿刺成功率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.

Background: Pain resulting from therapeutic procedures and injections is a prevalent source of stress for children. Immediate side effects of pain in infants include syncope, irritability, sleep disturbances, and nutritional issues. This study aimed to investigate the effects of oral melatonin on alleviating pain and anxiety in pediatric patients undergoing venipuncture.

Methods: This double-blind, randomized controlled trial was conducted in the pediatric emergency ward. Patients were randomly assigned to one of two groups; the intervention group received 0.5 mg/kg of oral melatonin (maximum 5 mg) 30 min before venipuncture, while the placebo group received an equivalent amount of a placebo 30 min before the procedure. Using the Face, Legs, Activity, Cry, Consolability (FLACC) scale, postcanulation fear, pain severity, compliance, and potential side effects were evaluated.

Results: In total, 202 patients (113 male and 89 female) in the intervention and control groups were included in the analysis. The mean pain score during venipuncture was 1.52±3.04 in the intervention group and 2.04±6.57 in the control group (P<0.001). In the intervention group, only 19 (18.8%) patients reported pain during venipuncture, whereas 79 (78.2%) patients in the control group reported pain (P<0.001). Less than half (44.6%) of the patients in the intervention group experienced anxiety during venipuncture, while the majority (94.1%) of the patients in the control group exhibited anxiety (P<0.001). The venipuncture success rate was 60.4% in the intervention group and 51.5% in the control group (P=0.257).

Conclusion: Administering 0.5 mg/kg of oral Melatonin 30 min before venipuncture reduces procedure-related pain and anxiety in pediatric patients and may be associated with higher venipuncture success rates.

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来源期刊
Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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5.90%
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