羧基二咪唑（CDI）可在常温下促进羧酸和硫醇的直接瞬时硫代酯化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-02 DOI:10.1039/d4ob01376j

Biman Bera , Upasi Goswami , Sujan Sk , Mrinal K. Bera

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引用次数: 0

摘要

本研究公开了一种简单而高效的方法，用于合成多种硫酯衍生物。羧酸和硫醇之间的酯化反应是在常温下进行的。该反应的显著特点是反应时间短、产率高、操作简便、官能团耐受性广。此外，在克级规模上精确制备硫代酯类化合物表明其工业应用前景广阔。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Carbonyldiimidazole (CDI) promoted direct and instantaneous thio-esterification of a carboxylic acid and thiol at ambient temperature†

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Carbonyldiimidazole (CDI) promoted direct and instantaneous thio-esterification of a carboxylic acid and thiol at ambient temperature†

A simple yet efficient method is disclosed for the synthesis of a diverse range of thioester derivatives. Carbonyldiimidazole promoted esterification between a carboxylic acid and thiol was carried out at ambient temperature. The short reaction time, excellent yield, operational ease and wide functional group tolerance are the notable features of the reaction. Furthermore, the precise preparation of thioesters on a gram scale suggests the promising prospects for its industrial application.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.