使用标准 T1 模体验证超高对比度分减反转复原技术。

IF 2.7 4区医学 Q2 BIOPHYSICS

NMR in Biomedicine Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI:10.1002/nbm.5269

Mark Bydder, Fadil Ali, Paul Condron, Daniel M Cornfeld, Gil Newburn, Eryn E Kwon, Maryam Tayebi, Miriam Scadeng, Tracy R Melzer, Samantha J Holdsworth, Graeme M Bydder

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引用次数: 0

摘要

分割减法反转复原（dSIR）是一种高 T1 对比技术，可显示脑外伤和缺氧性损伤患者白质的变化。这些变化可以用 T1 的微小差异来解释；但迄今为止，还没有使用标准参考对该技术进行独立验证。本研究发展了 dSIR 信号的理论，并使用 NIST/ISMRM T1 模型进行了验证。研究探讨了非理想情况，包括噪声偏差和有限重复时间（TR）的影响，从而为反转恢复采集引入了最佳有效的 TR。结果显示与理论计算结果非常吻合。

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Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T₁ phantom.

The divided subtracted inversion recovery (dSIR) is a high T₁ contrast technique that shows changes in white matter in patients with traumatic brain injury and hypoxic injury. The changes can be explained by small differences in T₁; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST/ISMRM T₁ phantom. Non-idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. Results show excellent agreement with theoretical calculations.

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来源期刊

NMR in Biomedicine 医学-光谱学

CiteScore

6.00

自引率

10.30%

发文量

209

审稿时长

3-8 weeks

期刊介绍： NMR in Biomedicine is a journal devoted to the publication of original full-length papers, rapid communications and review articles describing the development of magnetic resonance spectroscopy or imaging methods or their use to investigate physiological, biochemical, biophysical or medical problems. Topics for submitted papers should be in one of the following general categories: (a) development of methods and instrumentation for MR of biological systems; (b) studies of normal or diseased organs, tissues or cells; (c) diagnosis or treatment of disease. Reports may cover work on patients or healthy human subjects, in vivo animal experiments, studies of isolated organs or cultured cells, analysis of tissue extracts, NMR theory, experimental techniques, or instrumentation.