Iivo Hetemäki, T Petteri Arstila, Eliisa Kekäläinen
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引用次数: 0
摘要
由 IKZF2 基因编码的转录因子 Helios 在调节性 T 细胞中发挥着重要作用,它能稳定 T 细胞的抑制表型。Helios 主要在调节性 T 细胞中表达,其表达范围还包括效应 T 细胞、滤泡调节性 T 细胞、B 细胞和先天类淋巴细胞群。最近,我们对因IKZF2变体损伤而导致先天性免疫错误的患者进行了特征描述,并对健康人的淋巴细胞进行了转化研究,从而加深了我们对Helios在控制人类适应性免疫系统中的多方面作用的了解。除了稳定调节性T细胞外,Helios在引导效应T细胞成熟方面的作用研究较少。在缺乏功能性 Helios 的情况下,效应 T 细胞会获得更多的炎症表型,并容易衰老。Helios 的表达缺失会破坏生殖中心反应的调控,通常会导致低丙种球蛋白血症或 B 细胞自身免疫。本综述总结了对小鼠和人类的研究结果,以全面了解转录因子Helios对适应性免疫系统的影响。
Helios-Illuminating the way for lymphocyte self-control.
Transcription factor Helios, encoded by the IKZF2 gene, has an important role in regulatory T cells by stabilizing their suppressive phenotype. While Helios is prominently expressed in regulatory T cells, its expression extends beyond to include effector T cells, follicular regulatory T cells, B cells, and innate-like lymphocyte populations. Recent characterizations of patients with inborn error of immunity due to damaging IKZF2 variants coupled with translational research on lymphocytes from healthy individuals, have increased our understanding on Helios' multifaceted role in controlling the human adaptive immune system. A less studied role for Helios beyond the stabilizing of regulatory T cells has emerged in directing effector T cell maturation. In the absence of functional Helios, effector T cells acquire more inflammatory phenotype and are prone to senescence. Loss of Helios expression disrupts the regulation of the germinal centre reaction, often resulting in either hypogammaglobulinemia or B cell autoimmunity. This review summarizes findings from studies in both mice and men offering a comprehensive understanding of the impact of the transcription factor Helios on the adaptive immune system.
期刊介绍:
Immunology is one of the longest-established immunology journals and is recognised as one of the leading journals in its field. We have global representation in authors, editors and reviewers.
Immunology publishes papers describing original findings in all areas of cellular and molecular immunology. High-quality original articles describing mechanistic insights into fundamental aspects of the immune system are welcome. Topics of interest to the journal include: immune cell development, cancer immunology, systems immunology/omics and informatics, inflammation, immunometabolism, immunology of infection, microbiota and immunity, mucosal immunology, and neuroimmunology.
The journal also publishes commissioned review articles on subjects of topical interest to immunologists, and commissions in-depth review series: themed sets of review articles which take a 360° view of select topics at the heart of immunological research.