{"title":"Dauricine：药理活性综述。","authors":"Ke-Qian Chen, Shu-Zhi Wang, Hai-Bo Lei, Xiang Liu","doi":"10.2147/DDDT.S471352","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dauricine is an important natural organic compound in <i>Menispermum dauricum</i>, which often has significant biological activity.</p><p><strong>Purpose: </strong>The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.</p><p><strong>Methods: </strong>Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to \"dauricine\" published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles.</p><p><strong>Results: </strong>Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuroprotection, anti-cancer, anti-arrhythmia, anti-inflammatory and anti-diabetes.</p><p><strong>Conclusion: </strong>Dauricine has a potential value in the treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of dauricine.</p>","PeriodicalId":11290,"journal":{"name":"Drug Design, Development and Therapy","volume":"18 ","pages":"4371-4385"},"PeriodicalIF":4.7000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444063/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dauricine: Review of Pharmacological Activity.\",\"authors\":\"Ke-Qian Chen, Shu-Zhi Wang, Hai-Bo Lei, Xiang Liu\",\"doi\":\"10.2147/DDDT.S471352\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Dauricine is an important natural organic compound in <i>Menispermum dauricum</i>, which often has significant biological activity.</p><p><strong>Purpose: </strong>The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.</p><p><strong>Methods: </strong>Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to \\\"dauricine\\\" published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles.</p><p><strong>Results: </strong>Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuroprotection, anti-cancer, anti-arrhythmia, anti-inflammatory and anti-diabetes.</p><p><strong>Conclusion: </strong>Dauricine has a potential value in the treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of dauricine.</p>\",\"PeriodicalId\":11290,\"journal\":{\"name\":\"Drug Design, Development and Therapy\",\"volume\":\"18 \",\"pages\":\"4371-4385\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444063/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Design, Development and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/DDDT.S471352\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Design, Development and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DDDT.S471352","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：目的：本综述旨在系统总结和探讨近年来金丝桃碱的药理活性及其作用机制：方法：利用 Web of Science（121 篇）和 PubMed 数据库（97 篇）检索 2000 年至 2024 年间发表的与 "金丝桃碱 "相关的文章。同时，通过筛选这些文章，我们对道里碱的药理活性进行了分类：结果：新的证据表明，牛磺酸具有多种药理活性，包括神经保护、抗癌、抗心律失常、抗炎和抗糖尿病等：结论：牛磺酸具有治疗多种疾病的潜在价值。我们希望这篇综述能为金牛血碱的治疗开发和未来研究做出贡献。
Background: Dauricine is an important natural organic compound in Menispermum dauricum, which often has significant biological activity.
Purpose: The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.
Methods: Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to "dauricine" published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles.
Results: Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuroprotection, anti-cancer, anti-arrhythmia, anti-inflammatory and anti-diabetes.
Conclusion: Dauricine has a potential value in the treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of dauricine.
期刊介绍：
Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications.
The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas.
Specific topics covered by the journal include:
Drug target identification and validation
Phenotypic screening and target deconvolution
Biochemical analyses of drug targets and their pathways
New methods or relevant applications in molecular/drug design and computer-aided drug discovery*
Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes)
Structural or molecular biological studies elucidating molecular recognition processes
Fragment-based drug discovery
Pharmaceutical/red biotechnology
Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products**
Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development
Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing)
Preclinical development studies
Translational animal models
Mechanisms of action and signalling pathways
Toxicology
Gene therapy, cell therapy and immunotherapy
Personalized medicine and pharmacogenomics
Clinical drug evaluation
Patient safety and sustained use of medicines.
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