生物活性化合物对创伤后应激障碍治疗的影响。

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Olha Strilbytska, Oleksandr Koliada, Volodymyr Lushchak, Oleh Lushchak
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引用次数: 0

摘要

创伤后应激障碍(PTSD)是一种精神疾病,发生在经历过战斗暴露、童年身体虐待、性暴力、人身攻击、事故等创伤事件的人身上。由于创伤后应激障碍难以诊断和治疗,医学、精神病学、生物化学和康复学等领域都在积极研究创伤后应激障碍。创伤后应激障碍具有明显的合并症特征,并伴有抑郁和焦虑。目前针对创伤后应激障碍症状的治疗策略包括心理治疗和药物治疗。天然提取的化合物可为情绪障碍提供治疗效果,且不会产生令人不快的副作用。食物中的生物活性化合物具有抗氧化、抗炎和保护神经等功效。在此,我们将介绍在各种动物模型和人体实验研究中评估过的一些生物活性物质的治疗功效。生物活性化合物的抗焦虑、抗抑郁和抗痴呆活性强调了它们治疗创伤后应激障碍合并症的潜力。此外,还讨论了假定的作用机制,为了解它们在人类心理健康方面的潜力提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Bioactive Compounds on PTSD Treatment.

Post-traumatic Stress Disorder (PTSD) is a psychiatric disease that arises in individuals who have experienced a traumatic event such as combat exposure, childhood physical abuse, sexual violence, physical assault, an accident, etc. Being difficult to diagnose and treat, PTSD is actively studied in areas of medicine, psychiatry, biochemistry, and rehabilitation. PTSD is characterized by significant comorbidity and is accompanied by depression and anxiety. Current treatment strategies for PTSD symptoms include psychotherapy and medications. Naturally derived compounds can offer therapeutic benefits for mood disorders without unpleasant side effects. Bioactive compounds found in food exhibit beneficial effects such as antioxidant, anti-inflammatory, and neuroprotective activities. Here, we describe the promising therapeutic benefits of a number of bioactive substances that have been evaluated in a variety of animal models and human experimental studies. Anxiolytic, antidepressant, and antidementia activities of bioactive compounds emphasize their potential for treating PTSD comorbidities. Hypothetical mechanisms of actions are also discussed, providing insights into their potential for human mental health.

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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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