熨平 MAFLD：以肝脏铁蛋白沉积为治疗目标

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2024-10-01 DOI:10.1016/j.cmet.2024.09.005

Tuo Shao, Raymond T. Chung

引用次数: 0

摘要

代谢功能障碍相关性脂肪肝（MAFLD）与铁代谢紊乱和铁变态反应有关，但这种关联的机制仍不清楚。王福弟研究小组1 利用动物模型、人类队列和多组学数据证明了铁失衡在 MAFLD 中的作用以及铁螯合剂 FerroTerminator 1 (FOT1) 的治疗潜力。

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Ironing out MAFLD: Therapeutic targeting of liver ferroptosis

Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with iron metabolism disorders and ferroptosis, but the mechanisms underlying this association remain unclear. Fudi Wang’s group¹ used animal models, human cohorts, and multi-omics data to demonstrate the role of iron imbalance in MAFLD and the therapeutic potential of the iron chelator FerroTerminator 1 (FOT1).

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.