胎盘素通过 PTGS2、NR3C1 和 PPARA 信号通路对小鼠肝损伤的保护作用

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2024-09-28 DOI:10.1016/j.jff.2024.106459

Xu-Qiang Liu , Wen-Jing Shao , Xiao-Peng Liu , Yu Zhang , Hui Liu , Jin-Mei Wang , Changyang Ma

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引用次数: 0

摘要

本研究探讨了胎盘菜提取物（PP-a）在缓解急性肝损伤方面的活性成分和机制。通过非靶向代谢组学分析，在PP-a中发现了102个化合物，其中32个被认为是治疗肝损伤的活性化合物。通过网络药理学分析，观察到 PP-a 的肝损伤靶点（2 0 3 个）。动物实验表明，PP-a 能明显减少炎症因子，增加抗氧化作用，修复损伤的肝组织，进一步有效改善肝功能。此外，PTGS2和NR3C1的mRNA表达量明显降低，而PPARA的mRNA表达量则因PP-a而在CCl4诱导的小鼠中明显增加。这些结果表明，胎盘素可能是通过调节 PTGS2、NR3C1 和 PPARA 的 mRNA 表达而发挥保肝作用的。对于 PP-a，L-组氨酸、N-乙酰基-D-异亮氨酸、15-氧代环己烷和棕榈酸可能在保护 CCl4 引起的小鼠肝损伤中发挥了关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Protective effects of Pleurotus placentodes against liver injury in mice via the PTGS2, NR3C1 and PPARA signaling pathways

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Protective effects of Pleurotus placentodes against liver injury in mice via the PTGS2, NR3C1 and PPARA signaling pathways

This study explored the active ingredients and mechanism of Pleurotus placentodes extract (PP-a) in alleviating acute liver injury. According to un-targeted metabolomics analysis, 102 compounds were identified in PP-a, 32 were regarded as active compounds for treating liver injury. PP-a’s targets (2 0 3) were observed for liver injury by network pharmacology analysis. Animal tests showed that PP-a significantly reduce inflammatory factors, increase anti-oxidative effects, and repair injured liver tissues, further effectively improving liver function. In addition, the mRNA expression of PTGS2 and NR3C1 was significantly reduced, while the mRNA expression of PPARA was significantly increased in CCl₄-induced mice as a result of PP-a. These results suggest that P. placentodes exerts hepatoprotective effects probably by regulating the mRNA expression of PTGS2, NR3C1 and PPARA. For PP-a, L-Histidine, N-Acetyl-D-alloisoleucine, 15-OxoEDE and palmitic acid probably play a critical role in protecting against liver injury in CCl₄-indcued mice.

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.