一步法合成压电混合 BNNT/BaTiO3 复合材料及其在骨组织工程中的应用

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-30 DOI:10.1016/j.jmbbm.2024.106758

Zehra Çobandede , Mustafa Çulha

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引用次数: 0

摘要

具有压电特性的纳米材料可显著提高聚合物在组织工程应用中的适用性。在本研究中，我们报告了一步合成由钛酸钡和氮化硼纳米管组成的新型混合压电复合材料。这种复合材料具有独特的微观结构，包括纳米片、三角形氮化硼结构和纤维状氮化硼纳米管构型，有助于增强其压电特性。该复合材料被纳入壳聚糖基组织支架，并在体外进行了评估。在支架上培养的电反应人类成骨细胞在细胞生长过程中受到低频超声波刺激。评估了压电复合材料支架上成骨细胞的生物相容性、细胞粘附性、碱性磷酸酶活性和矿化度。结果表明，混合压电复合材料显著增强了壳聚糖基支架的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

One-step synthesis of a piezoelectric hybrid BNNT/BaTiO3 composite and its application in bone tissue engineering

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One-step synthesis of a piezoelectric hybrid BNNT/BaTiO3 composite and its application in bone tissue engineering

Nanomaterials with piezoelectric properties can significantly improve the applicability of polymers used in tissue engineering applications. In this study, we report the one-step synthesis of a novel hybrid piezoelectric composite comprising barium titanates and boron nitride nanotubes. This composite is distinguished by its unique microstructures, including nanoflakes, triangular boron nitride structures, and fiber-like boron nitride nanotube configurations, which contribute to its enhanced piezoelectric properties. The composite was incorporated into a chitosan-based tissue scaffold and evaluated in vitro. Electric-responsive Human Osteoblast cells cultured on the scaffolds are exposed to low-frequency ultrasound stimulation during cell growth. The biocompatibility, cell adhesion, alkaline phosphatase activities, and mineralization of osteoblast cells on the piezo-composite scaffolds were evaluated. The results show that the hybrid piezoelectric composite significantly enhances the properties of chitosan-based scaffold.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.