LINC00365 作为晚期肾细胞癌患者全肾切除术的潜在生物标记物

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-09-27 DOI:10.1016/j.prp.2024.155630

Fatemeh Taghavinia , Iman Akhlaghipour , Alireza Golshan , Azadeh Aarabi , Mohammad Reza Abbaszadegan , Meysam Moghbeli

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引用次数: 0

摘要

背景肾细胞癌（RCC）是全球最常见的泌尿系统癌症之一，肿瘤早期预后良好。然而，转移性 RCC 患者的预后较差。因此，有必要对 RCC 进展的分子生物学进行评估，以便为这些患者引入有效的诊断和治疗标志物。长非编码 RNA（lncRNA）在 RCC 进展过程中的分子机制调控中起着关键作用。方法收集50例新鲜RCC肿瘤组织及其正常边缘，评估LINC00365的表达水平以及与RCC患者临床病理特征的可能相关性。结果与男性相比，女性的LINC00365有显著的上调（P=0.050）。在接受全肾切除术的RCC患者中，晚期肿瘤比原发期肿瘤有明显的LINC00365上调（P=0.035）。结论鉴于LINC00365在晚期RCC肿瘤和60岁以上接受过全肾切除术的患者中的表达显著增加，它可作为筛查老年高危人群的有用诊断标志物。研究还发现，女性RCC患者的肿瘤样本中LINC00365表达水平升高，这表明LINC00365有可能作为高危女性的性别特异性诊断标志物。尽管如此，要想将LINC00365作为可靠的临床诊断标志物，有必要对RCC患者血清样本中的LINC00365水平进行评估。

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LINC00365 as a potential biomarker for total nephrectomy in advanced-stage renal cell carcinoma patients

Background

Renal cell carcinoma (RCC) is one of the most frequent urological cancers globally that has a good prognosis in the early tumor stages. However, there is a poor prognosis in metastatic RCC patients. Therefore, it is needed to evaluate the molecular biology of RCC progression to introduce the efficient diagnostic and therapeutic markers in these patients. Long non-coding RNAs (lncRNAs) have key roles in regulation of molecular mechanisms during RCC progression. In the present study, we assessed the levels of LINC00365 expressions in RCC patients to suggest that as a tumor marker in these patients.

Methods

Fifty fresh RCC tumor tissues and their normal margins were collected to assess the levels of LINC00365 expressions and probable correlations with clinicopathological features of RCC patients.

Results

There was significant LINC00365 up regulation in females compared with males (p=0.050). Among the RCC patients with total nephrectomy, there was a significant LINC00365 up regulation in advanced stage compared with primary stage tumors (p=0.035). RCC patients older than 60 years old who were undergone the total nephrectomy had also significant LINC00365 up regulation compared with RCC patients younger than 60 years old (p=0.039).

Conclusions

given the significant increase in LINC00365 expression in advanced stage RCC tumors and patients over 60 years old who had total nephrectomy; it could serve as a useful diagnostic marker in screening programs for old high-risk individuals. It was also noticed that female RCC patients had elevated levels of LINC00365 expressions in their tumor samples, suggesting its potential use as a gender-specific diagnostic marker for high-risk females. Nevertheless, evaluating the levels of LINC00365 in serum samples of RCC patients is necessary to suggest that as a reliable diagnostic marker in clinical settings.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.