通过调节微RNA改善缺血性中风的针灸干预机制研究进展。

Q3 Medicine

针刺研究 Pub Date : 2024-08-25 DOI:10.13702/j.1000-0607.20230031

Cheng-Long Li, Wei Mao, Li-da Zhang, Wei Han, Xin Zhang, Ying Wang

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引用次数: 0

摘要

微RNA在缺血性中风（IS）的发生和发展中起着重要作用。大量研究表明，针灸干预可通过调节 miRNA 改善 IS 引起的神经功能障碍。本文从1）促进血管生成，增加脑血流量；2）抑制炎症反应；3）维持血脑屏障平衡，缓解脑水肿；4）调节程序性细胞死亡；5）促进神经元再生；6）改善突触可塑性等方面，总结了目前针灸通过调控miRNA改善IS机制的研究进展。这些 miRNA 相关机制可为后续研究提供参考。

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Progress of researches on the mechanisms of acupuncture intervention underlying improvement of ischemic stroke by regulating microRNAs.

MicroRNAs play an important role in the occurrence and development of ischemic stroke (IS). A lot of researches have shown that acupuncture intervention can improve IS-induced neural dysfunction by regulating miRNA. In the present paper, we summarized the current progress of researches on the mechanisms of acupuncture underlying improvement of IS via regulation of miRNA from 1) promoting angiogenesis and increasing cerebral blood flow, 2) inhibiting inflammatory response, 3) maintaining blood-brain barrier homeostasis and relieving brain edema, 4) regulating programmed cell death, 5) promoting neuron regeneration, and 6) improving synaptic plasticity. These miRNA -related mechanisms may provide a reference for the follow-up research .

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来源期刊

针刺研究 Medicine-Medicine (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Acupuncture Research was founded in 1976. It is an acupuncture academic journal supervised by the State Administration of Traditional Chinese Medicine, co-sponsored by the Institute of Acupuncture of the China Academy of Chinese Medical Sciences and the Chinese Acupuncture Association. This journal is characterized by "basic experimental research as the main focus, taking into account clinical research and reporting". It is the only journal in my country that focuses on reporting the mechanism of action of acupuncture. The journal has been changed to a monthly journal since 2018, published on the 25th of each month, and printed in full color. The manuscript acceptance rate is about 10%, and provincial and above funded projects account for about 80% of the total published papers, reflecting the latest scientific research results in the acupuncture field and has a high academic level. Main columns: mechanism discussion, clinical research, acupuncture anesthesia, meridians and acupoints, theoretical discussion, ideas and methods, literature research, etc.