年轻和卡介苗充足是非肌层浸润性膀胱癌获得最佳卡介苗疗效的关键因素。

IF 2.8 2区 医学 Q2 UROLOGY & NEPHROLOGY
Kang Liu, Rossella Nicoletti, Hongda Zhao, Xuan Chen, Hongwei Wu, Chi-Ho Leung, David D'Andrea, Ekaterina Laukhtina, Francesco Soria, Andrea Gallioli, Marcelo Langer Wroclawski, Daniele Castellani, Vineet Gauhar, Juan Gomez Rivas, Dmitry Enikeev, Paolo Gontero, Shahrokh F Shariat, Peter Ka-Fung Chiu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh
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引用次数: 0

摘要

目的研究老龄化对接受卡介苗(BCG)治疗的非肌层浸润性膀胱癌(NMIBC)患者生存结果的影响,以及老龄化与充分卡介苗治疗的协同作用:方法:将2001年至2020年接受卡介苗治疗的非肌层浸润性膀胱癌患者分为1组(70岁)。采用 Kaplan-Meier 法分析总生存期(OS)、癌症特异性生存期(CSS)、无复发生存期(RFS)和无进展生存期(PFS)。采用多变量 Cox 回归分析调整潜在的混杂因素,并估算危险比 (HR) 和 95% 置信区间 (CI)。根据卡介苗治疗充分与不足进行了分组分析:共纳入 2602 例 NMIBC 患者:第一组和第二组分别有 1051 例(40.4%)和 1551 例(59.6%)。中位随访时间为 11.0 年,第一组(70 岁)。在亚组分析中,与接受卡介苗不足治疗的第2组患者相比,接受足量卡介苗治疗的第1组患者的OS、CSS、RFS和PFS更佳,而接受足量卡介苗治疗的第2组患者的病情进展比接受卡介苗不足治疗的同组患者少41%:接受适当卡介苗治疗的年轻患者(70岁)与接受适当卡介苗治疗的年轻患者的PFS相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Young age and adequate BCG are key factors for optimal BCG treatment efficacy in non-muscle-invasive bladder cancer.

Objective: To investigate the impact of ageing on survival outcomes in Bacillus Calmette-Guérin (BCG) treated non-muscle invasive bladder cancer (NMIBC) patients and its synergy with adequate BCG treatment.

Method: Patients with NMIBC who received BCG treatment from 2001 to 2020 were divided into group 1 (< = 70 years) and group 2 (> 70 years). Overall Survival (OS), Cancer-Specific Survival (CSS), Recurrence-Free Survival (RFS), and Progression-Free Survival (PFS) were analyzed using the Kaplan-Meier method. Multivariable Cox regression analysis was used to adjust potential confounding factors and to estimate Hazard Ratio (HR) and 95% Confidence Interval (CI). Subgroup analysis was performed according to adequate versus inadequate BCG treatment.

Results: Overall, 2602 NMIBC patients were included: 1051 (40.4%) and 1551 (59.6%) in groups 1 and 2, respectively. At median follow-up of 11.0 years, group 1 (< = 70 years) was associated with better OS, CSS, and RFS, but not PFS as compared to group 2 (> 70 years). At subgroup analysis, patients in group 1 treated with adequate BCG showed better OS, CSS, RFS, and PFS as compared with inadequate BCG treatment in group 2, while patients in group 2 receiving adequate BCG treatment had 41% less progression than those treated with inadequate BCG from the same group.

Conclusions: Being younger (< = 70 years) was associated with better OS, CSS, and RFS, but not PFS. Older patients (> 70 years) who received adequate BCG treatment had similar PFS as those younger with adequate BCG treatment.

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来源期刊
World Journal of Urology
World Journal of Urology 医学-泌尿学与肾脏学
CiteScore
6.80
自引率
8.80%
发文量
317
审稿时长
4-8 weeks
期刊介绍: The WORLD JOURNAL OF UROLOGY conveys regularly the essential results of urological research and their practical and clinical relevance to a broad audience of urologists in research and clinical practice. In order to guarantee a balanced program, articles are published to reflect the developments in all fields of urology on an internationally advanced level. Each issue treats a main topic in review articles of invited international experts. Free papers are unrelated articles to the main topic.
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