在 T1 级息肉癌变病例中实施监控政策后,我们能期望其安全性有多高?

IF 1.4 Q4 GASTROENTEROLOGY & HEPATOLOGY
Cristina Mateos Sanchez, Elvira Quintanilla Lazaro, Luis Ramon Rabago
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引用次数: 0

摘要

在内镜下切除的息肉中,约有 7% 有腺癌病灶,而之前内镜下并无恶性证据。这就提出了一个问题:内镜切除术是否具有治愈性?此外,关于预后良好的内镜和组织学标准、适当的随访策略以及长期效果如何,目前还没有达成共识。Fábián等人的回顾性研究旨在评估内镜切除肿瘤与肿瘤外科手术相比,局部复发或远处转移的发生率。他们得出的结论是,无论选择哪种治疗策略,复发率都比文献中描述的要高,而且随访的依从性也很差。内镜下良性息肉经组织学证实为腺癌后的处理方法取决于是否存在之前描述的预后不良的组织学因素。如果不存在这些因素,且息肉已完全切除(R0),则应积极进行监测,因为内镜下切除被认为是治愈性的。这些结果再次强调,有必要进一步开展多中心临床实践研究,以获得更多证据,从而制定适当的治疗和随访策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?

Approximately 7% of the polyps resected endoscopically have an adenocarcinoma focus, with no previous endoscopic evidence of malignancy. This raises the question of whether endoscopic resection has been curative. Furthermore, there is no consensus on what the endoscopic and histological criteria for good prognosis are, the appropriate follow-up strategy and what are the long-term results. The aim of the retrospective study by Fábián et al was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic surgery. They concluded that, regardless of the treatment strategy chosen, there was a higher recurrence rate than described in the literature and that adherence to follow-up was poor. The management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological factors. If none of these factors are present and the polyp has been completely resected en bloc (R0), active surveillance is considered appropriate as endoscopic resection is deemed curative. These results highlight, once again, the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies.

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来源期刊
World Journal of Gastrointestinal Endoscopy
World Journal of Gastrointestinal Endoscopy GASTROENTEROLOGY & HEPATOLOGY-
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