间充质干细胞在肝脏再生中的作用机制：见解与未来方向。

IF 3.6 3区医学 Q3 CELL & TISSUE ENGINEERING

World journal of stem cells Pub Date : 2024-09-26 DOI:10.4252/wjsc.v16.i9.842

Yu-Xin Jin, Hang-Qi Hu, Jia-Cheng Zhang, Xi-Yan Xin, Yu-Tian Zhu, Yang Ye, Dong Li

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引用次数: 0

摘要

间充质干细胞（MSCs）是干细胞疗法的普遍来源，在调节先天性和适应性免疫反应方面发挥着至关重要的作用。非酒精性脂肪肝（NAFLD）的特点是甘油三酯在肝细胞中积累，涉及免疫系统激活，导致组织学变化、组织损伤和临床症状。蒋等人最近发表的一篇文章强调了间充质干细胞通过靶向各种分子通路（包括糖脂代谢、炎症、氧化应激、内质网应激和纤维化）缓解非酒精性脂肪肝进展的潜力。在这篇社论中，我们将对他们的研究进行评论，并讨论间充质干细胞疗法在治疗非酒精性脂肪肝方面的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanism of mesenchymal stem cells in liver regeneration: Insights and future directions.

Mesenchymal stem cells (MSCs) are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune responses. Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides in liver cells and involves immune system activation, leading to histological changes, tissue damage, and clinical symptoms. A recent publication by Jiang et al, highlighted the potential of MSCs to mitigate in NAFLD progression by targeting various molecular pathways, including glycolipid metabolism, inflammation, oxidative stress, endoplasmic reticulum stress, and fibrosis. In this editorial, we comment on their research and discuss the efficacy of MSC therapy in treating NAFLD.

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来源期刊

World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

7.80

自引率

4.90%

发文量

750

期刊介绍： The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.