利用病毒样颗粒和基于纳米颗粒的疫苗防治皮卡病毒感染。

IF 3.7 1区 农林科学 Q1 VETERINARY SCIENCES
Mei Ren, Sahibzada Waheed Abdullah, Chenchen Pei, Huichen Guo, Shiqi Sun
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引用次数: 0

摘要

脊髓灰质炎病毒科(Picornaviridae)是一种非包膜 ssRNA 病毒,可引起脊髓灰质炎、手足口病(HFMD)、甲型肝炎、脑炎、心肌炎和口蹄疫(FMD)等疾病。病毒样颗粒(VLPs)疫苗主要由病毒外壳蛋白自我组装形成的颗粒组成(对于包膜病毒,也可选择包膜蛋白)。它们不包含病毒基因组。另一方面,纳米颗粒疫苗(NPs)主要由自我组装的生物蛋白质或纳米材料组成,表面显示病毒抗原。病毒抗原以重复阵列的方式呈现在这些颗粒上,可引起动物强烈的免疫反应。VLPs 和 NPs 可以成为多价抗原呈递的强大平台。本综述总结了针对皮卡病毒的病毒样颗粒疫苗(VLP)和纳米颗粒疫苗(NP)的开发情况。通过详细介绍在抗击脊髓灰质炎病毒 (PV)、口蹄疫病毒 (FMDV)、肠道病毒 (EV)、塞内卡病毒 A (SVA) 和脑心肌炎病毒 (EMCV) 等各种皮卡病毒方面取得的进展,我们反过来强调了疫苗技术取得的重大进步。这些进步包括多样化的构建方法、表达系统、诱导免疫反应以及各种佐剂的使用。我们认为 VLPs 和 NPs 疫苗的持续开发和优化前景广阔。未来的研究重点应放在增强这些疫苗的免疫原性、稳定性和递送方法上。此外,扩大我们对这些疫苗与免疫系统之间相互作用的理解也至关重要。我们希望这些见解能够启发和指导研究人员更有效地对抗皮卡病毒感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of virus-like particles and nanoparticle-based vaccines for combating picornavirus infections.

Picornaviridae are non-enveloped ssRNA viruses that cause diseases such as poliomyelitis, hand-foot-and-mouth disease (HFMD), hepatitis A, encephalitis, myocarditis, and foot-and-mouth disease (FMD). Virus-like particles (VLPs) vaccines mainly comprise particles formed through the self-assembly of viral capsid proteins (for enveloped viruses, envelope proteins are also an option). They do not contain the viral genome. On the other hand, the nanoparticles vaccine (NPs) is mainly composed of self-assembling biological proteins or nanomaterials, with viral antigens displayed on the surface. The presentation of viral antigens on these particles in a repetitive array can elicit a strong immune response in animals. VLPs and NPs can be powerful platforms for multivalent antigen presentation. This review summarises the development of virus-like particle vaccines (VLPs) and nanoparticle vaccines (NPs) against picornaviruses. By detailing the progress made in the fight against various picornaviruses such as poliovirus (PV), foot-and-mouth disease virus (FMDV), enterovirus (EV), Senecavirus A (SVA), and encephalomyocarditis virus (EMCV), we in turn highlight the significant strides made in vaccine technology. These advancements include diverse construction methods, expression systems, elicited immune responses, and the use of various adjuvants. We see promising prospects for the continued development and optimisation of VLPs and NPs vaccines. Future research should focus on enhancing these vaccines' immunogenicity, stability, and delivery methods. Moreover, expanding our understanding of the interplay between these vaccines and the immune system will be crucial. We hope these insights will inspire and guide fellow researchers in the ongoing quest to combat picornavirus infections more effectively.

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来源期刊
Veterinary Research
Veterinary Research 农林科学-兽医学
CiteScore
7.00
自引率
4.50%
发文量
92
审稿时长
3 months
期刊介绍: Veterinary Research is an open access journal that publishes high quality and novel research and review articles focusing on all aspects of infectious diseases and host-pathogen interaction in animals.
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