精神分裂症的预后。

Q4 Medicine

Ugeskrift for laeger Pub Date : 2024-09-02 DOI:10.61409/V02240156

Marie Starzer, Helene Gjervig Hansen, Carsten Hjorthøj, Nikolai Albert, Merete Nordentoft

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引用次数: 0

摘要

精神症状和阴性症状是精神分裂症的核心特征，但对这些症状的长期病程却缺乏了解。抗精神病药物可以改善精神症状，但对阴性症状的作用有限。像 OPUS 这样的早期专业干预在持续进行时效果显著，但长期随访表明，并没有持久的疾病改变效果。18%的患者实现了临床痊愈，40%的患者在20年后症状得到缓解，但正如本综述所述，高死亡率和持续的阴性症状构成了尚未满足的治疗需求。

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The prognosis of schizophrenia.

Psychotic and negative symptoms are core features of schizophrenia but knowledge on the long-term course of these symptoms is lacking. While antipsychotics improve psychotic symptoms, they have limited effect on negative symptoms. Specialized early interventions like OPUS show great effects while ongoing but long-term follow-up indicates no lasting disease-modifying effects. 18% of patients achieved clinical recovery, and 40% obtained symptom remission after 20 years, but high mortality rates and continuous negative symptoms constitute an unmet treatment need, as argued in this review.

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来源期刊

Ugeskrift for laeger Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

345

期刊介绍： The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.