利用多参数超声成像鉴定尿道组织特征。

IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS
Haowei Tai , Kourosh Kalayeh , James A. Ashton-Miller , John O. DeLancey , J. Brian Fowlkes
{"title":"利用多参数超声成像鉴定尿道组织特征。","authors":"Haowei Tai ,&nbsp;Kourosh Kalayeh ,&nbsp;James A. Ashton-Miller ,&nbsp;John O. DeLancey ,&nbsp;J. Brian Fowlkes","doi":"10.1016/j.ultras.2024.107481","DOIUrl":null,"url":null,"abstract":"<div><div>A decrease in urethral closure pressure is one of the primary causes of stress urinary incontinence in women. Atrophy of the urethral muscles is a primary factor in the 15 % age-related decline in urethral closure pressure per decade. Incontinence not only affects the well-being of women but is also a leading cause of nursing home admission. The objective of this research was to develop a noninvasive test to assess urethral tissue microenvironmental changes using multiparametric ultrasound (mpUS) imaging technique. Transperineal B-scan ultrasound (US) data were captured using clinical scanners equipped with curvilinear or linear transducers. Imaging was performed on volunteers from our institution medical center (n = 15, 22 to 76 y.o.) during Valsalva maneuvers. After expert delineation of the region of interest in each frame, the central axis of the urethra was automatically defined to determine the angle between the urethra and the US beam for further analysis. By integrating angle-dependent backscatter with radiomic texture feature analysis, a mpUS technique was developed to identify biomarkers that reflect subtle microstructural changes expected within the urethral tissue. The process was repeated when the urethra and US beam were at a fixed angle. Texture selection was conducted for both angle-dependent and angle-independent results to remove redundancies. Ultimately, a distinct biomarker was derived using a random forest regression model to compute the urethra score based on features selected from both processes. Angle-dependent backscatter analysis shows that the calculated slope of US mean image intensity decreased by 0.89 (±0.31) % annually, consistent with the expected atrophic disorganization of urethral tissue structure and the associated reduction in urethral closure pressure with age. Additionally, textural analysis performed at a specific angle (i.e., 40 degrees) revealed changes in gray level nonuniformity, skewness, and correlation by 0.08 (±0.04) %, −2.16 (±1.14) %, and −0.32 (±0.35) % per year, respectively. The urethra score was ultimately determined by combining data selected from both angle-dependent and angle-independent analysis strategies using a random forest regression model with age, yielding an R<sup>2</sup> value of 0.96 and a p-value less than 0.001. The proposed mpUS tissue characterization technique not only holds promise for guiding future urethral tissue characterization studies without the need for tissue biopsies or invasive functional testing but also aims to minimize observer-induced variability. By leveraging mpUS imaging strategies that account for angle dependence, it provides more accurate assessments. Notably, the urethra score, calculated from US images that reflect tissue microstructural changes, serves as a potential biomarker providing clinicians with deeper insight into urethral tissue function and may aid in diagnosing and managing related conditions while helping to determine the causes of incontinence.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"145 ","pages":"Article 107481"},"PeriodicalIF":3.8000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urethral tissue characterization using multiparametric ultrasound imaging\",\"authors\":\"Haowei Tai ,&nbsp;Kourosh Kalayeh ,&nbsp;James A. Ashton-Miller ,&nbsp;John O. DeLancey ,&nbsp;J. Brian Fowlkes\",\"doi\":\"10.1016/j.ultras.2024.107481\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A decrease in urethral closure pressure is one of the primary causes of stress urinary incontinence in women. Atrophy of the urethral muscles is a primary factor in the 15 % age-related decline in urethral closure pressure per decade. Incontinence not only affects the well-being of women but is also a leading cause of nursing home admission. The objective of this research was to develop a noninvasive test to assess urethral tissue microenvironmental changes using multiparametric ultrasound (mpUS) imaging technique. Transperineal B-scan ultrasound (US) data were captured using clinical scanners equipped with curvilinear or linear transducers. Imaging was performed on volunteers from our institution medical center (n = 15, 22 to 76 y.o.) during Valsalva maneuvers. After expert delineation of the region of interest in each frame, the central axis of the urethra was automatically defined to determine the angle between the urethra and the US beam for further analysis. By integrating angle-dependent backscatter with radiomic texture feature analysis, a mpUS technique was developed to identify biomarkers that reflect subtle microstructural changes expected within the urethral tissue. The process was repeated when the urethra and US beam were at a fixed angle. Texture selection was conducted for both angle-dependent and angle-independent results to remove redundancies. Ultimately, a distinct biomarker was derived using a random forest regression model to compute the urethra score based on features selected from both processes. Angle-dependent backscatter analysis shows that the calculated slope of US mean image intensity decreased by 0.89 (±0.31) % annually, consistent with the expected atrophic disorganization of urethral tissue structure and the associated reduction in urethral closure pressure with age. Additionally, textural analysis performed at a specific angle (i.e., 40 degrees) revealed changes in gray level nonuniformity, skewness, and correlation by 0.08 (±0.04) %, −2.16 (±1.14) %, and −0.32 (±0.35) % per year, respectively. The urethra score was ultimately determined by combining data selected from both angle-dependent and angle-independent analysis strategies using a random forest regression model with age, yielding an R<sup>2</sup> value of 0.96 and a p-value less than 0.001. The proposed mpUS tissue characterization technique not only holds promise for guiding future urethral tissue characterization studies without the need for tissue biopsies or invasive functional testing but also aims to minimize observer-induced variability. By leveraging mpUS imaging strategies that account for angle dependence, it provides more accurate assessments. Notably, the urethra score, calculated from US images that reflect tissue microstructural changes, serves as a potential biomarker providing clinicians with deeper insight into urethral tissue function and may aid in diagnosing and managing related conditions while helping to determine the causes of incontinence.</div></div>\",\"PeriodicalId\":23522,\"journal\":{\"name\":\"Ultrasonics\",\"volume\":\"145 \",\"pages\":\"Article 107481\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ultrasonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0041624X24002440\",\"RegionNum\":2,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasonics","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0041624X24002440","RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ACOUSTICS","Score":null,"Total":0}
引用次数: 0

摘要

尿道闭合压下降是导致女性压力性尿失禁的主要原因之一。尿道肌肉萎缩是导致尿道闭合压力每十年下降 15% 的主要因素。尿失禁不仅影响妇女的健康,也是导致妇女入住疗养院的主要原因。这项研究的目的是利用多参数超声(mpUS)成像技术,开发一种评估尿道组织微环境变化的无创检测方法。经会阴 B-scan 超声波(US)数据由配备曲线或线性换能器的临床扫描仪采集。本机构医疗中心的志愿者(n = 15,22 至 76 岁)在做瓦尔萨尔瓦动作时进行了成像。在专家对每帧图像中的感兴趣区进行划定后,自动定义尿道的中心轴,以确定尿道与 US 光束之间的角度,从而进行进一步分析。通过将角度依赖性反向散射与放射学纹理特征分析相结合,开发出了一种 mpUS 技术,用于识别反映尿道组织内预期微观结构变化的生物标记物。当尿道和 US 光束呈固定角度时,重复这一过程。对与角度相关和与角度无关的结果都进行了纹理选择,以去除冗余。最终,使用随机森林回归模型,根据从两个过程中选择的特征计算尿道得分,得出了一个独特的生物标记。与角度相关的反向散射分析表明,US 平均图像强度的计算斜率每年下降 0.89 (±0.31) %,这与预期的尿道组织结构萎缩紊乱以及随着年龄增长尿道闭合压力的降低是一致的。此外,以特定角度(即 40 度)进行的纹理分析显示,灰度不均匀度、偏斜度和相关性每年分别变化 0.08 (±0.04) %、-2.16 (±1.14) % 和 -0.32 (±0.35) %。尿道评分最终是通过使用年龄随机森林回归模型结合从角度依赖性和角度无关性分析策略中选取的数据确定的,R2 值为 0.96,P 值小于 0.001。所提出的 mpUS 组织特征描述技术不仅有望指导未来的尿道组织特征描述研究,而无需进行组织活检或侵入性功能测试,而且还能最大限度地减少观察者引起的变异。通过利用考虑角度依赖性的 mpUS 成像策略,它能提供更准确的评估。值得注意的是,根据反映组织微观结构变化的 US 图像计算出的尿道评分是一种潜在的生物标志物,可让临床医生更深入地了解尿道组织的功能,有助于诊断和处理相关疾病,同时帮助确定尿失禁的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Urethral tissue characterization using multiparametric ultrasound imaging
A decrease in urethral closure pressure is one of the primary causes of stress urinary incontinence in women. Atrophy of the urethral muscles is a primary factor in the 15 % age-related decline in urethral closure pressure per decade. Incontinence not only affects the well-being of women but is also a leading cause of nursing home admission. The objective of this research was to develop a noninvasive test to assess urethral tissue microenvironmental changes using multiparametric ultrasound (mpUS) imaging technique. Transperineal B-scan ultrasound (US) data were captured using clinical scanners equipped with curvilinear or linear transducers. Imaging was performed on volunteers from our institution medical center (n = 15, 22 to 76 y.o.) during Valsalva maneuvers. After expert delineation of the region of interest in each frame, the central axis of the urethra was automatically defined to determine the angle between the urethra and the US beam for further analysis. By integrating angle-dependent backscatter with radiomic texture feature analysis, a mpUS technique was developed to identify biomarkers that reflect subtle microstructural changes expected within the urethral tissue. The process was repeated when the urethra and US beam were at a fixed angle. Texture selection was conducted for both angle-dependent and angle-independent results to remove redundancies. Ultimately, a distinct biomarker was derived using a random forest regression model to compute the urethra score based on features selected from both processes. Angle-dependent backscatter analysis shows that the calculated slope of US mean image intensity decreased by 0.89 (±0.31) % annually, consistent with the expected atrophic disorganization of urethral tissue structure and the associated reduction in urethral closure pressure with age. Additionally, textural analysis performed at a specific angle (i.e., 40 degrees) revealed changes in gray level nonuniformity, skewness, and correlation by 0.08 (±0.04) %, −2.16 (±1.14) %, and −0.32 (±0.35) % per year, respectively. The urethra score was ultimately determined by combining data selected from both angle-dependent and angle-independent analysis strategies using a random forest regression model with age, yielding an R2 value of 0.96 and a p-value less than 0.001. The proposed mpUS tissue characterization technique not only holds promise for guiding future urethral tissue characterization studies without the need for tissue biopsies or invasive functional testing but also aims to minimize observer-induced variability. By leveraging mpUS imaging strategies that account for angle dependence, it provides more accurate assessments. Notably, the urethra score, calculated from US images that reflect tissue microstructural changes, serves as a potential biomarker providing clinicians with deeper insight into urethral tissue function and may aid in diagnosing and managing related conditions while helping to determine the causes of incontinence.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Ultrasonics
Ultrasonics 医学-核医学
CiteScore
7.60
自引率
19.00%
发文量
186
审稿时长
3.9 months
期刊介绍: Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed. As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信