恶性胶质瘤重塑神经元回路：治疗机会和抗癫痫药物的再利用。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI:10.1016/j.trecan.2024.09.003

Cesar Nava Gonzales, Mikias B Negussie, Saritha Krishna, Vardhaan S Ambati, Shawn L Hervey-Jumper

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引用次数: 0

摘要

肿瘤相关性癫痫是弥漫性胶质瘤患者最常见的症状。最近的证据表明，胶质瘤的增殖和侵袭需要突触活动的驱动。关于使用抗癫痫药物（AEDs）与化疗联合进行抗肿瘤治疗，1 级、2 级和 3 级证据十分有限。此外，还没有发现最有针对性的中心机制。抗癫痫药物治疗的最佳时机仍然未知。以异常神经元活动为靶点是治疗胶质瘤的一个前景广阔的途径。临床生物标志物可能有助于确定最有可能从AEDs中获益的患者。需要高质量的证据来指导治疗决策。

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Malignant glioma remodeling of neuronal circuits: therapeutic opportunities and repurposing of antiepileptic drugs.

Tumor-associated epilepsy is the most common presenting symptom in patients diagnosed with diffuse gliomas. Recent evidence illustrates the requirement of synaptic activity to drive glioma proliferation and invasion. Class 1, 2, and 3 evidence is limited regarding the use of antiepileptic drugs (AEDs) as antitumor therapy in combination with chemotherapy. Furthermore, no central mechanism has emerged as the most targetable. The optimal timing of AED regimen remains unknown. Targeting aberrant neuronal activity is a promising avenue for glioma treatment. Clinical biomarkers may aid in identifying patients most likely to benefit from AEDs. Quality evidence is needed to guide treatment decisions.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.