EZHIP 在弥漫性中线胶质瘤中的作用:与癌基因的呼应?

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI:10.1016/j.trecan.2024.09.002
Afraah Cassim, Matthew D Dun, David Gallego-Ortega, Fatima Valdes-Mora
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引用次数: 0

摘要

泽斯特增强子抑制蛋白(EZHIP)通常在生殖细胞发育过程中表达,在各种癌症中被归类为癌睾抗原(CTA)。2020 年,4% 的弥漫中线胶质瘤(DMGs)被证明异常表达 EZHIP,这与 DMG 标志性组蛋白 H3 K27M(H3K27M)同源突变如出一辙。与 H3K27M 相似,EZHIP 也是多聚酶抑制复合体 2(PRC2)的负调控因子,可导致全球表观基因组重塑。在这篇论文中,我们探讨了 H3K27M- 和 EZHIP-DMGs 的异同,重点是它们共同的功能特征:PRC2 抑制、它们的遗传和表观基因组图谱、起源细胞中可能存在的差异以及治疗途径。即将开展的有关EZHIP的研究将有助于更好地了解它在胶质瘤发生和DMG治疗中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EZHIP's role in diffuse midline glioma: echoes of oncohistones?

The enhancer of zeste inhibitory protein (EZHIP) is typically expressed during germ cell development and has been classified as a cancer-testis antigen (CTA) in various cancers. In 2020, 4% of diffuse midline gliomas (DMGs) were shown to aberrantly express EZHIP, mirroring the DMG hallmark histone H3 K27M (H3K27M) oncohistone mutation. Similar to H3K27M, EZHIP is a negative regulator of polycomb repressive complex 2 (PRC2), leading to global epigenomic remodeling. In this opinion, we explore the similarities and disparities between H3K27M- and EZHIP-DMGs with a focus on their shared functional hallmark of PRC2 inhibition, their genetic and epigenomic landscapes, plausible differences in the cell of origin, and therapeutic avenues. Upcoming research on EZHIP will help better understand its role in gliomagenesis and DMG therapy.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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