用于疾病建模和治疗开发的组织工程三维平台。

IF 5.1 2区医学 Q2 CELL & TISSUE ENGINEERING

Tissue Engineering. Part B, Reviews Pub Date : 2024-10-09 DOI:10.1089/ten.TEB.2024.0212

Erika E Wheeler, J Kent Leach

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引用次数: 0

摘要

目前正在研究三维（3D）组织工程模型，以再现组织结构和功能，从而克服传统 2D 培养和临床前动物模型的局限性。本综述重点介绍了三维平台的最新进展，这些平台旨在为影响心血管、胃肠道、骨髓、神经、生殖和肺系统等多种组织和器官的疾病建立体外模型。我们讨论了当前的工程组织模型技术，强调了建模组织和疾病的优势、局限性和重要注意事项。最后，我们讨论了未来提高组织发育和疾病三维模型可靠性所需的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tissue-Engineered Three-Dimensional Platforms for Disease Modeling and Therapeutic Development.

Three-dimensional (3D) tissue-engineered models are under investigation to recapitulate tissue architecture and functionality, thereby overcoming limitations of traditional two-dimensional cultures and preclinical animal models. This review highlights recent developments in 3D platforms designed to model diseases in vitro that affect numerous tissues and organs, including cardiovascular, gastrointestinal, bone marrow, neural, reproductive, and pulmonary systems. We discuss current technologies for engineered tissue models, highlighting the advantages, limitations, and important considerations for modeling tissues and diseases. Lastly, we discuss future advancements necessary to enhance the reliability of 3D models of tissue development and disease.

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来源期刊

Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

12.80

自引率

1.60%

发文量

150

期刊介绍： Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.