量化德国心血管风险极高的高脂血症患者 "距离低密度脂蛋白血症目标的距离":一项回顾性索赔数据库分析。

IF 2.6 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ksenija Stach, Hartmut Richter, Uwe Fraass, Alexandra Stein
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引用次数: 0

摘要

背景和目的:本研究量化了心血管风险极高且高脂血症未得到控制的患者 "距离低密度脂蛋白胆固醇目标的距离"。距离低密度脂蛋白胆固醇目标 "的定义是:为达到欧洲心脏病学会/欧洲动脉粥样硬化学会 2016 年或 2019 年指南中规定的低密度脂蛋白胆固醇(LDL-C)目标,需要降低的低密度脂蛋白胆固醇(LDL-C)水平的百分比:这项回顾性分析使用了 IQVIA Disease Analyzer 数据库中的数据,纳入了 2014 年至 2018 年间主要接受初级保健医生、糖尿病专家或心脏病专家治疗的患者,这些患者被诊断为高脂血症,并进行了首次 LDL-C 测量(指数事件),同时具有一个或多个心血管风险因素。主要结果是评估高脂血症未得到控制的患者比例,并对这些患者的 "低密度脂蛋白胆固醇目标距离 "进行分类:分析了 32963 名患者的数据(初级保健医生队列、糖尿病队列和心脏病队列中的患者人数分别为 27159 人、3873 人和 1931 人)。大多数患者在指数时的低密度脂蛋白胆固醇水平(⩾70 mg/dL;⩾1.8 mmol/L)未得到控制(在初级保健医生队列、糖尿病队列和心脏病队列中分别为 91.0%、86.4% 和 94.0%)。对 "距离低密度脂蛋白胆固醇目标 "的分析表明,每个队列中约有三分之一的患者需要将低密度脂蛋白胆固醇水平相对于指数降低 50%,才能达到低密度脂蛋白胆固醇目标(初级保健医生队列、糖尿病队列和心脏病队列中的患者比例分别为 35.8%、43.7% 和 28.4%)。大多数低密度脂蛋白胆固醇(LDL-C)水平未得到控制的患者在指标发布后 36 个月仍未达到 LDL-C 控制目标(在全科医生组、糖尿病组和心脏病组中分别为 86.8%、81.7% 和 90.2%):结论:大多数高脂血症患者的低密度脂蛋白胆固醇水平未得到控制。对 "距离低密度脂蛋白胆固醇目标 "的分析表明,大多数患者需要大幅降低低密度脂蛋白胆固醇水平,才能达到低密度脂蛋白胆固醇目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantifying the 'distance to LDC-goal' in patients at very high cardiovascular risk with hyperlipidaemia in Germany: a retrospective claims database analysis.

Background and objectives: This study quantified the 'distance to LDL-C goal' in patients at very high cardiovascular risk with uncontrolled hyperlipidaemia. 'Distance to LDL-C goal' was defined as the percentage by which low-density lipoprotein cholesterol (LDL-C) levels needed to be reduced to achieve the LDL-C goals specified in the 2016 or 2019 European Society of Cardiology/European Atherosclerosis Society guidelines.

Design and methods: This retrospective analysis using data from the IQVIA Disease Analyzer database included patients who were predominantly treated by a primary care physician, diabetologist or cardiologist between 2014 and 2018, with a diagnosis of hyperlipidaemia and an initial LDL-C measurement (index event) and one or more cardiovascular risk factors. The primary outcome was to assess the proportion of patients with uncontrolled hyperlipidaemia and to classify the 'distance to LDL-C goal' in these patients.

Results: Data from 32,963 patients were analysed (n = 27,159, n = 3873 and n = 1931 patients in the primary care physician, diabetology and cardiology cohorts, respectively). Most patients had uncontrolled LDL-C levels (⩾70 mg/dL; ⩾1.8 mmol/L) at index (91.0%, 86.4% and 94.0% of patients in the primary care physician, diabetology and cardiology cohorts, respectively). Analysis of the 'distance to LDL-C goal' indicated that approximately one-third of patients in each cohort required an LDL-C level reduction of up to 50% relative to index to achieve their LDL-C goal (35.8%, 43.7% and 28.4% of patients in the primary care physician, diabetology and cardiology cohorts, respectively). LDL-C control was not achieved at 36 months post-index in most patients with uncontrolled LDL-C levels (86.8%, 81.7% and 90.2% of patients in the primary care physician, diabetology and cardiology cohorts, respectively).

Conclusion: LDL-C levels were uncontrolled in most patients with hyperlipidaemia. Analysis of the 'distance to LDL-C goal' showed that most patients required a substantial LDL-C level reduction to achieve their LDL-C goal.

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来源期刊
Therapeutic Advances in Cardiovascular Disease
Therapeutic Advances in Cardiovascular Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.50
自引率
0.00%
发文量
11
审稿时长
9 weeks
期刊介绍: The journal is aimed at clinicians and researchers from the cardiovascular disease field and will be a forum for all views and reviews relating to this discipline.Topics covered will include: ·arteriosclerosis ·cardiomyopathies ·coronary artery disease ·diabetes ·heart failure ·hypertension ·metabolic syndrome ·obesity ·peripheral arterial disease ·stroke ·arrhythmias ·genetics
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