客观测量的睡眠时间每晚变化对健康大学生血糖的影响。

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2024-09-26 DOI:10.1093/sleep/zsae224
Alyssa S C Ng, E Shyong Tai, Michael W L Chee
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引用次数: 0

摘要

研究目的方法:119 名大学生使用 Oura Ring 2 和连续血糖监测仪(CGM)进行了长达 14 天的睡眠测量。在 69 名在整个研究期间摄入标准化饮食的人中,多层次模型检查了睡眠持续时间、时间和效率与每日 CGM 曲线之间的关联。另外,在 58 名参与者中,使用多层次模型评估了他们在 7 天的测试餐挑战中的餐后血糖反应。参与者还在一夜自由睡眠后进行了一次口服葡萄糖耐量测试,并在相对于个人习惯睡眠时间限制 1-2 小时后再次进行了口服葡萄糖耐量测试。结果显示,夜间睡眠对血糖和胰岛素偏移、HOMA-IR 和松田指数没有显著影响:结果:夜间睡眠对第二天的 CGM 曲线、餐后血糖或夜间平均血糖水平没有明显影响(所有 Ps 均大于 0.05)。较长的睡眠时间与较低的当晚血糖变异性相关(所有Ps均为0.05):结论:年轻、健康成年人的血糖处理可能比以前认为的更能适应现实生活中睡眠模式的波动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of night-to-night variations in objectively measured sleep on blood glucose in healthy university students.

Study objectives: We examined associations between daily variations in objectively measured sleep and blood glucose in a sample of non-diabetic young adults to complement laboratory studies on how sleep affects blood glucose levels.

Methods: 119 university students underwent sleep measurement using an Oura Ring 2 and continuous glucose monitoring (CGM) for up to 14 days. In 69 individuals who consumed a standardised diet across the study, multilevel models examined associations between sleep duration, timing and efficiency and daily CGM profiles. Separately, in 58 individuals, multilevel models were used to evaluate postprandial glycaemic responses to a test meal challenge on 7 days. Participants also underwent oral glucose tolerance testing once after a night of ad libitum sleep, and again following a night of sleep restriction by 1-2 hours relative to that individual's habitual sleep duration. Between-condition glucose and insulin excursions, HOMA-IR and Matsuda index were compared.

Results: Nocturnal sleep did not significantly influence following-day CGM profiles, postprandial glucose, or nocturnal mean glucose levels (all Ps>0.05). Longer sleep durations were associated with lower same-night glucose variability (all Ps<0.001). However, the range of variation of sugar levels was small and unlikely to be of functional significance. Considering naps in the analysis did not alter the findings. Sleep restriction by an average of 1.73 hours (SD=0.97) did not significantly impact excursions in glucose or insulin or insulin sensitivity the following morning (all Ps>0.05).

Conclusions: Glucose handling in young, healthy adults may be more resilient to real-life fluctuations in sleep patterns than previously thought.

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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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