性激素及其受体参与新疆典型卡波西肉瘤的发病机制

IF 2 4区 医学 Q3 DERMATOLOGY
Meng Wei, Xin Jiang, Yi Bian, Jun-Wei Fan
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引用次数: 0

摘要

研究目的本研究旨在检测新疆典型卡波西肉瘤(CKS)患者体内雄激素受体(AR)和雌激素受体(ER)的表达,并评估这些患者的血清性激素水平。目的是探索新疆卡波西肉瘤诊断和治疗的潜在新方向和新靶点:病例组由 2014 年至 2021 年在我院就诊的 35 名确诊为 CKS 的患者组成。对照组由同期来院就诊的35名化脓性肉芽肿(PG)患者组成,采用倾向评分匹配法(PSM)筛选。研究人员采用免疫组织化学方法检测确诊为中卡介苗和化脓性肉芽肿患者的石蜡包埋组织样本中的AR、人类疱疹病毒8型(HHV-8)和ER。此外,还使用酶联免疫吸附试验(ELISA)定量检测了35名CKS患者和35名PG患者的血清性激素水平:结果:AR在CKS组和PG组中的表达都相对较弱,其中PG组的表达略强于CKS组。相反,CKS 组的 ER 表达明显高于 PG 组(P < 0.05)。此外,CKS 组的血清睾酮(T)水平升高,而 PG 组的血清雌二醇(E2)水平升高(p < 0.05):结论:性激素及其受体与新疆 CKS 的发病机制有关。使用ER拮抗剂可能是研究和治疗CKS的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Involvement of Sex Hormones and Their Receptors in the Pathogenesis of Classic Kaposi's Sarcoma in Xinjiang.

Objective: This study aims to examine the expression of androgen receptor (AR) and estrogen receptor (ER) in patients with classic Kaposi's sarcoma (CKS) in Xinjiang, as well as to assess the serum levels of sex hormones in these patients. The objective is to explore potential new directions and targets for diagnosing and treating CKS in Xinjiang.

Methods: The case group comprised 35 patients diagnosed with CKS who presented at our hospital from 2014 to 2021. The control group consisted of 35 patients with pyogenic granuloma (PG) who visited the hospital during the same period, selected using propensity score matching (PSM). Immunohistochemistry was used to detect AR, human herpesvirus type 8 (HHV-8), and ER in paraffin-embedded tissue samples from patients diagnosed with CKS and PG. Additionally, enzyme-linked immunosorbent assay (ELISA) was used to quantitatively measure serum sex hormone levels in the 35 patients with CKS and 35 patients with PG.

Results: AR expression was relatively weak in both the CKS and PG groups, with the PG group exhibiting a slightly stronger expression than the CKS group. Conversely, the expression of ER was significantly higher in the CKS group compared to the PG group (p < 0.05). Additionally, serum testosterone (T) levels were elevated in the CKS group, while serum estradiol (E2) levels were higher in the PG group (p < 0.05).

Conclusion: Sex hormones and their receptors are implicated in the pathogenesis of CKS in Xinjiang. The use of ER antagonists may represent a novel avenue for research and treatment of CKS.

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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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