静脉注射血细胞分泌物能改善骨关节炎犬的临床症状。

IF 2.2 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2024-09-27 DOI:10.1016/j.rvsc.2024.105422

J.C. Alves , A. Santos , Ana Filipe , L. Miguel Carreira

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引用次数: 0

摘要

我们的目的是评估静脉注射（IV）血细胞分泌物（BCS）与关节内注射（IA）相比的效果。在这项交叉研究中，10只患有双侧髋关节骨关节炎的狗最初被分配到IA组（IAG）。经过 180 天的随访后，同样的 10 只动物被分配到静脉注射组（IVG）。IAG 组的每个髋关节接受一次 3 毫升 BCS 的静脉注射，IVG 组的每个髋关节接受一次 6 毫升 BCS 的静脉注射。每次治疗后，分别在第 0、8、15、30、60、90、120、150 和 180 天进行随访。每次随访都会获得犬简易疼痛量表（分为疼痛干扰评分 - PIS 和疼痛严重程度评分 - PSS）、利物浦犬骨关节炎（LOAD）和犬矫形指数（COI，分为功能、步态、僵硬度和生活质量）。结果采用 Mann-Whitney 检验进行分析，并计算和比较 Kaplan-Meier 估计值，P

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The intravenous administration of blood cell secretome can improve clinical signs in dogs with osteoarthritis

We aimed to evaluate the effect of the intravenous (IV) administration of blood cell secretome (BCS) compared to its intra-articular (IA) administration.

In this cross-over study, ten dogs with bilateral hip osteoarthritis were initially assigned to an IA group (IAG). After a 180-day follow-up, the same 10 animals were assigned to an IV group (IVG). IAG received a single IA administration of 3 ml of BCS per hip joint, and IVG received a single 6 ml IV administration of BCS. Following each treatment, follow-up was conducted on days 0, 8, 15, 30, 60, 90, 120, 150, and 180. In each follow-up, copies of the Canine Brief Pain Inventory (divided into pain interference score - PIS and Pain Severity Score - PSS), Liverpool Osteoarthritis in Dogs (LOAD), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) were obtained. Results were analyzed with the Mann-Whitney test, and Kaplan-Meier estimators were calculated and compared, p < 0.05.

The animals had a mean age of 7.6 ± 2.9 years and bodyweight of 27.8 ± 3.6 kg. Seven hips were classified as moderate osteoarthritis, and three as severe. No differences were found between groups from days 0 to +60d, with both groups showing clinically significant improvements. Improvements in the IAG lasted up to +120d. Kaplan-Meier estimators showed that dogs in IAG took longer to record the considered events. IVG also showed positive clinically significant results with different instruments.

IV administration of BCS can improve the overall condition of dogs with hip OA, but the IA administration produces longer-lasting results.

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.