CSF IL-6 水平升高与精神疾病中的焦虑和沮丧可能存在关联。

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY
Takako Enokida, Kotaro Hattori, Kaori Okabe, Takamasa Noda, Miho Ota, Noriko Sato, Shintaro Ogawa, Megumi Tatsumi, Mikio Hoshino, Hiroshi Kunugi, Kazuyuki Nakagome
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引用次数: 0

摘要

目的:神经炎症是多种精神疾病的重要致病因素。我们曾报道精神分裂症和重度抑郁症患者脑脊液中的白细胞介素-6水平升高。本研究旨在探讨白细胞介素-6水平与焦虑和挫折感(各种精神疾病共有的负价症状)之间可能存在的关联:我们纳入了 129 名精神障碍患者和 70 名对照组患者。用免疫测定试剂盒测定脑脊液和血浆中的白细胞介素-6水平,并用状态-特质焦虑量表和基本心理需求满足和挫折量表评估心理症状。为了检查区域脑血流量,患者接受了磁共振成像动脉自旋标记分析:结果:脑脊液白细胞介素-6水平与国家-特质焦虑量表-特质焦虑(r = 0.25,P = 0.046)和基本心理需求满足和挫折量表-自主挫折评分(r = 0.29,P = 0.018)显著相关。与其他患者相比,脑脊液白细胞介素-6水平异常高的患者(定义>对照组的97.5百分位数)的特质焦虑(P = 0.035)和自主挫折感(P = 0.026)得分更高,左侧颞上回、双侧伏隔核和小脑的区域脑血流量显著增加:结论:脑脊液白细胞介素-6升高的患者构成了与焦虑和自主挫折相关的精神障碍亚群,这可能与特定脑区功能的改变有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Possible association of elevated CSF IL-6 levels with anxiety and frustration in psychiatric disorders.

Aim: Neuroinflammation is an important causal factor for a variety of psychiatric disorders. We previously reported increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and major depressive disorder. The present study aimed to examine the possible association of interleukin-6 levels with anxiety and frustration, negative valence symptoms shared in various psychiatric disorders.

Methods: We included 129 patients with psychiatric disorders and 70 controls. CSF and plasma interleukin-6 levels were measured by immunoassay kits, and psychological symptoms were assessed with the State-Trait Anxiety Inventory, and the Basic Psychological Need Satisfaction and Frustration Scale. To examine regional cerebral blood flow, patients underwent arterial spin labeling analysis using magnetic resonance imaging.

Results: Cerebrospinal fluid interleukin-6 levels were significantly correlated with State-Trait Anxiety Inventory-trait anxiety (r = 0.25, P = 0.046) and Basic Psychological Need Satisfaction and Frustration Scale-autonomy frustration scores (r = 0.29, P = 0.018). Patients with abnormally high cerebrospinal fluid interleukin-6 levels (defined >97.5 percentile of the controls) had higher scores for trait anxiety (P = 0.035) and autonomy frustration (P = 0.026), and significantly increased regional cerebral blood flow in the left superior temporal gyrus, bilateral nucleus accumbens, and cerebellum than the remaining patients.

Conclusion: Patients with elevated cerebrospinal fluid interleukin-6 constitute a subpopulation of psychiatric disorders associated with anxiety and autonomy frustration, which may be related to altered functions in specific brain areas.

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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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