治疗血脂异常的全缘草科与十字花科植物:研究现状与未来展望。临床研究的系统回顾和荟萃分析》。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Eugenia Piragine, Marco Andrea Malanima, Costanza Ceccanti, Lucia Guidi, Alma Martelli, Ersilia Lucenteforte, Vincenzo Calderone
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引用次数: 0

摘要

血脂异常是心血管疾病的风险因素之一。临床前研究表明,来自大蒜(Allium sativum L.)和西兰花(Brassica oleracea L.)等大蒜科和十字花科植物的有机硫化合物具有潜在的降脂作用。然而,它们的临床疗效尚存争议,尤其是在 "无药 "患者中。本研究旨在总结有关含有机硫化合物的提取物在血脂异常患者中降脂作用的证据。研究在四个数据库(Medline、Scopus、Embase 和 CENTRAL)中进行了检索,检索时间从开始到 2023 年 10 月 11 日。研究结果为血脂参数与基线相比的变化。使用 R 软件对提取的数据进行随机效应荟萃分析。效应大小以平均差(MD)和 95% 置信区间(CI)表示。证据的确定性采用 GRADE 方法进行评估。在审查的 28 项研究中,22 项被纳入荟萃分析(发表时间:1981-2022 年)。结果显示,全缘草提取物可显著降低总胆固醇[MD:-15.2 mg/dL;95% CI:-21.3;-9.1]和低密度脂蛋白胆固醇水平[MD:-12.0 mg/dL;95% CI:-18.1;-5.7],但证据的确定性较低。相反,芸香科植物提取物的降脂特性仍有待探索。我们的研究结果支持在高胆固醇血症患者中使用全缘木科植物提取物,但还需要进行更多高质量的研究。我们的研究表明,芸苔属植物提取物可能具有很高的营养保健/植物治疗潜力,我们建议进一步探索芸苔属植物提取物的功效,从而为血脂异常的治疗开辟新的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alliaceae versus Brassicaceae for Dyslipidemia: State of the Art and Future Perspectives. Systematic Review and Meta-Analysis of Clinical Studies.

Dyslipidemia is a risk factor for cardiovascular diseases. Preclinical studies have shown that organosulfur compounds from the Alliaceae and Brassicaceae plants, such as garlic (Allium sativum L.) and broccoli (Brassica oleracea L.), have potential lipid-lowering effects. However, their clinical efficacy is controversial, especially in "drug-free" patients. The aim of this work was to summarize evidence on the lipid-lowering properties of extracts containing organosulfur compounds in patients with dyslipidemia. Studies were searched in four databases (Medline, Scopus, Embase, and CENTRAL), from inception to October 11, 2023.Controlled clinical studies on patients with dyslipidemia receiving Alliaceae or Brassicaceae were included. The outcome was the change in lipid parameters from baseline. Random-effect meta-analysis of the extracted data was performed using R software. The effect size was expressed as mean difference (MD) and 95% confidence interval (CI). The certainty of evidence was assessed with the GRADE approach. Out of 28 studies that were reviewed, 22 were included in the meta-analysis (publication period: 1981-2022). Results showed that Alliaceae extracts significantly reduce total cholesterol [MD: -15.2 mg/dL; 95% CI: -21.3; -9.1] and low-density lipoprotein cholesterol levels [MD: -12.0 mg/dL; 95% CI: -18.1; -5.7], although with low certainty of evidence. Conversely, the lipid-lowering properties of Brassicaceae extracts are still unexplored. Our results support the use of Alliaceae extracts in patients with hypercholesterolemia, but future high-quality studies are needed. Our work suggests further exploration of the efficacy of Brassicaceae extracts, which may have high nutraceutical/phytotherapeutic potential, opening new perspectives in the management of dyslipidemia.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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