用于新型给药系统的纳米药物的最新进展。

Q2 Pharmacology, Toxicology and Pharmaceutics
Kai Bin Liew, Ee Va Koh, Xue Er Kong, Nurdina Aleyah Ismail, Rabiatul Adawiyah Abu Bakar, Phei Er Kee, Syed Haroon Khalid, Hiu Ching Haroon Phang
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引用次数: 0

摘要

纳米粒子的应用领域广泛,包括农业、食品、化妆品、化工、机械工程、汽车以及石油和天然气行业。在医疗领域,纳米粒子因其表面积大、溶解度高、溶解速度快和生物利用率高而备受关注。纳米药物经过专门设计,可将药物物质精确地输送到目标组织和细胞,从而在优化疗效的同时最大限度地减少潜在的不良反应。此外,纳米药物还具有加快治疗起效、减少剂量、最大限度地减少进食和禁食状态之间的变化以及提高患者依从性等优势。科学家和行业利益相关者对纳米药物研究的兴趣与日俱增,凸显了纳米药物在疾病管理和癌症治疗等各种医疗应用领域的潜力。本综述探讨了高效给药的理想纳米粒子的独特特性,探索了目前医学中使用的纳米粒子类型,并深入研究了纳米药物的应用,包括药物和基因递送以及透皮给药。这篇综述提供了对纳米药物领域的见解,有助于新型给药系统的开发和提高纳米技术在医疗保健领域的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems.

Nanoparticles have found applications across diverse sectors, including agriculture, food, cosmetics, chemicals, mechanical engineering, automotive, and oil and gas industries. In the medical field, nanoparticles have garnered considerable attention due to their great surface area, high solubility, rapid dissolution, and enhanced bioavailability. Nanopharmaceuticals are specifically designed to precisely deliver drug substances to targeted tissues and cells, aiming to optimize therapeutic efficacy while minimizing potential adverse effects. Furthermore, nanopharmaceuticals offer advantages, such as expedited therapeutic onset, reduced dosages, minimized variability between fed and fasted states, and enhanced patient compliance. The increasing interest in nanopharmaceuticals research among scientists and industry stakeholders highlights their potential for various medical applications from disease management to cancer treatment. This review examines the distinctive characteristics of ideal nanoparticles for efficient drug delivery, explores the current types of nanoparticles utilized in medicine, and delves into the applications of nanopharmaceuticals, including drug and gene delivery, as well as transdermal drug administration. This review provides insights into the nanopharmaceuticals field, contributing to the development of novel drug delivery systems and enhancing the potential of nanotechnology in healthcare.

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来源期刊
Pharmaceutical nanotechnology
Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.20
自引率
0.00%
发文量
46
期刊介绍: Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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