用于肥胖症控制的植物活性物质:整合纳米医学,实现有效传递。

IF 5.9 2区 医学 Q1 NUTRITION & DIETETICS
Ashok Kumar Mandal, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Abdulrahman Alhamyani, Alhussain Aodah, Nabil K Alruwaili, Sharifah Zamiah Binti Syed Abdul Kadir, Rambha Kumari Mandal, Rami A Almalki, Jonathan A Lal, Mahfoozur Rahman
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引用次数: 0

摘要

肥胖症是一个全球关注的健康问题,亟待调查和管理。虽然有人工合成的抗肥胖药物,但它们的副作用风险很高,而且疗效参差不齐。因此,世界各地越来越多地使用天然化合物来治疗肥胖症。天然化合物(主要是多酚类物质)可以通过强化食品和营养素来有效、安全地控制肥胖,这一观点得到了大量实验研究的有力支持。本综述重点介绍肥胖症的发病机理,同时回顾了一系列用于治疗肥胖症的植物活性物质的功效。它详细介绍了酶抑制、能量消耗、食欲抑制、脂肪细胞分化、脂质代谢和肠道微生物群调节等机制。全面的体外、体内和临床前研究强调了植物活性物质在防治肥胖症方面的前景,并对这些研究进行了深入探讨。然而,生物利用率和新陈代谢不良等挑战限制了它们的潜力。纳米药物的进步可能会克服这些限制,为提高植物活性成分的功效提供新的途径。不过,在将植物活性物质用作肥胖症的主要治疗方法之前,必须进行严格和有针对性的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery.

Obesity is a global health concern that requires urgent investigation and management. While synthetic anti-obesity medications are available, they come with a high risk of side-effects and variability in their efficacy. Therefore, natural compounds are increasingly being used to treat obesity worldwide. The proposition that naturally occurring compounds, mainly polyphenols, can be effective and safer for obesity management through food and nutrient fortification is strongly supported by extensive experimental research. This review focuses on the pathogenesis of obesity while reviewing the efficacy of an array of phytoactives used for obesity treatment. It details mechanisms such as enzyme inhibition, energy expenditure, appetite suppression, adipocyte differentiation, lipid metabolism, and modulation of gut microbiota. Comprehensive in vitro, in vivo, and preclinical studies underscore the promise of phytoactives in combating obesity, which have been thoroughly reviewed. However, challenges, such as poor bioavailability and metabolism, limit their potential. Advances in nanomedicines may overcome these constraints, offering a new avenue for enhancing the efficacy of phytoactives. Nonetheless, rigorous and targeted clinical trials are essential before applying phytoactives as a primary treatment for obesity.

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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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