极小肝性脑病患者大脑功能网络动态度中心性的改变及其与代谢紊乱的关系

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Hui-Wei Huang, Rong-Hua Liu, Jing-Yi Zeng, Dan Li, Jian-Qi Li, Hua-Jun Chen
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引用次数: 0

摘要

目的:研究动态度中心性(dDC)改变及其与极小肝性脑病(MHE)代谢紊乱和认知障碍的关系:58名肝硬化患者(22名MHE患者,36名非MHE患者[NHE])和25名健康对照者接受了静息态功能磁共振成像、1H-磁共振波谱和基于心理测量肝性脑病评分(PHES)的神经认知检查。我们获得了双侧后扣带皮层和楔前皮层的代谢物比率,包括谷氨酸和谷氨酰胺(Glx)/总肌酸(tCr)、肌醇(mI)/tCr、总胆碱/tCr和N-乙酰天冬氨酸/tCr。对于每个体素,度中心性被计算为其与大脑中其他体素的功能连通性之和;滑动窗口相关性被用来计算每个体素的dDC:结果:我们观察到,从 NHE 到 MHE,Glx/tCr 逐步增加,mI/tCr 逐步减少。在双侧扣带回后皮层和楔前皮层(感兴趣区 [ROI1])、双侧额叶中上回和扣带回前皮层(ROI2)以及左侧尾状脑中观察到了组间 dDC 差异。ROI2中的dDC(r = 0.450,P 结论:ROI1中的dDC与ROI2中的dDC存在显著差异:我们的研究结果表明,MHE 患者大脑网络的动态紊乱与代谢失调和神经认知障碍有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alteration of dynamical degree centrality in brain functional network and its association with metabolic disorder in minimal hepatic encephalopathy.

Purpose: To investigate dynamical degree centrality (dDC) alteration and its association with metabolic disturbance and cognitive impairment in minimal hepatic encephalopathy (MHE).

Methods: Fifty-eight cirrhotic patients (22 with MHE, 36 without MHE [NHE]) and 25 healthy controls underwent resting-state functional magnetic resonance imaging, 1H-magnetic resonance spectroscopy, and neurocognitive examination based on the Psychometric Hepatic Encephalopathy Score (PHES). We obtained metabolite ratios in the bilateral posterior cingulate cortex and precuneus, including glutamate and glutamine (Glx)/total creatine (tCr), myo-inositol (mI)/tCr, total choline/tCr, and N-acetyl aspartate/tCr. For each voxel, degree centrality was calculated as the sum of its functional connectivity with other voxels in the brain; and sliding-window correlation was used to calculate dDC per voxel.

Results: We observed a stepwise increase in Glx/tCr and a decrease in mI/tCr from NHE to MHE. The intergroup dDC differences were observed in the bilateral posterior cingulate cortex and precuneus (region of interest [ROI1]), bilateral superior-medial frontal gyrus and anterior cingulate cortex (ROI2), and left caudate head. The dDC in ROI2 (r = 0.450, P < 0.001) and mI/tCr (r = 0.297, P = 0.024) was correlated with PHES. Significant correlations were found between dDC in ROI1 and Glx/tCr (r = - 0.413, P = 0.001) and mI/tCr (r = 0.554, P < 0.001). The dDC in ROI2, Glx/tCr, and mI/tCr showed potential for distinguishing NHE from MHE (areas under the curve = 0.859, 0.655, and 0.672, respectively).

Conclusion: Our findings suggested dynamic brain network disorganization in MHE, which was associated with metabolic derangement and neurocognitive impairment.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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