阿尔茨海默病精神症状的神经解剖相关性和预测因素：系统回顾和荟萃分析。

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES

Neuropsychologia Pub Date : 2024-09-24 DOI:10.1016/j.neuropsychologia.2024.109006

Sara Scarfo , Antonella M.A. Marsella , Loulouda Grigoriadou , Yashar Moshfeghi , William J. McGeown

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引用次数: 0

摘要

背景：精神症状（幻觉和妄想）是阿尔茨海默病（AD）患者的一种神经精神症状：精神病性症状（幻觉和妄想）是阿尔茨海默病（AD）患者的一种神经精神症状：本系统综述旨在全面收集、分析和评估研究阿尔茨海默病（AD）患者脑区/脑网络与精神病性症状之间关系的证据：根据PRISMA指南制定的方案已在OSF（https://osf.io/tg8xp/）上预先注册。使用 PubMed、Web of Science 和 PsycInfo 进行了检索。根据数据可用性进行了部分基于坐标的荟萃分析（CBMA）：选取了 82 篇论文：发现妄想主要与右侧额颞叶脑区和脑岛有关；幻觉主要与前枕叶脑区有关；两者都经常与前扣带回皮层有关。根据 14 篇关于妄想症的论文结果进行的 CBMA 研究发现，一个妄想症群位于额叶，一个位于普坦门，一个较小的妄想症群位于脑岛：现有证据表明，主要位于右额叶、前扣带回皮层和颞枕区的关键脑区似乎是AD和MCI患者不同表现的精神病症状的基础。与妄想有关的额颞区可能是无法吸收正确信息和考虑其他可能性的基础（这可能会产生并维持妄想信念），而突出网络（前扣带回皮层和岛叶）的功能障碍可能会影响内部和外部刺激的识别；与幻觉有关的前枕叶区可能表明感官处理能力减弱和预测处理能力不理想，这些因素共同导致了对刺激的误解和错误认知；前颞叶区和枕叶区以及前扣带皮层与精神病群有关。

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Neuroanatomical correlates and predictors of psychotic symptoms in Alzheimer's disease: A systematic review and meta-analysis

Background

Psychotic symptoms (hallucinations and delusions) are a type of neuropsychiatric symptom found during Alzheimer's Disease (AD).

Objective

This systematic review aims to comprehensively capture, analyse, and evaluate the body of evidence that has investigated associations between brain regions/networks and psychotic symptoms in AD.

Methods

The protocol, created according to the PRISMA guidelines, was pre-registered on OSF (https://osf.io/tg8xp/). Searches were performed using PubMed, Web of Science and PsycInfo. A partial coordinate-based meta-analysis (CBMA) was performed based on data availability.

Results

Eighty-two papers were selected: delusions were found to be associated mainly with right fronto-temporal brain regions and the insula; hallucinations mainly with fronto-occipital areas; both were frequently associated with the anterior cingulate cortex. The CBMA, performed on the findings of fourteen papers on delusions, identified a cluster in the frontal lobe, one in the putamen, and a smaller one in the insula.

Conclusions

The available evidence highlights that key brain regions, predominantly in the right frontal lobe, the anterior cingulate cortex, and temporo-occipital areas, appear to underpin the different manifestations of psychotic symptoms in AD and MCI. The fronto-temporal areas identified in relation to delusions may underpin a failure to assimilate correct information and consider alternative possibilities (which might generate and maintain the delusional belief), and dysfunction within the salience network (anterior cingulate cortex and insula) may suggest a contribution for how internal and external stimuli are identified; the fronto-occipital areas linked to hallucinations may indicate diminished sensory processing and non-optimal predictive processing, that together contribute to misinterpretation of stimuli and misperceptions; the fronto-temporal and occipital areas, as well as the anterior cingulate cortex were linked to the psychotic cluster.

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来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.