银杏叶提取物(EGb 761)治疗突发性感音神经性听力损失的疗效和血液流变学:一项回顾性研究。

IF 1.3 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY
Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI:10.4103/nah.nah_73_24
Huajun Dong, Miaomiao Liu, Lingyan Rong, Shaohui Yang, Jinwei Wang
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引用次数: 0

摘要

研究目的本研究旨在分析银杏叶提取物(EGb 761)对突发性感音神经性听力损失(SSNHL)的治疗效果及其对血液流变学的影响:回顾性分析山东省文登中医骨伤医院2020年5月至2023年5月收治的突发性感音神经性听力损失(SSNHL)患者的临床资料。根据不同的临床治疗方案,患者被分为对照组(常规治疗)和给药组(常规治疗 + EGb 761)。两组患者均接受了为期 10 天的药物治疗。随后,比较两组患者的听阈、血液流变学参数(血液高剪切粘度、血液低剪切粘度、血浆粘度和血小板聚集率)以及炎症因子和血清水平(C 反应蛋白、白细胞介素-6、肿瘤坏死因子-α 和可溶性血管细胞粘附分子-1):本研究共有 120 例患者,其中对照组 66 例,治疗组 54 例。治疗后,给药组的总有效率(90.74% 对 72.73%)明显高于对照组(P 值小于 0.05)。用药组的听阈、血液流变学指标、炎症因子和血清水平明显低于对照组(P值<0.05):与常规治疗相比,联合使用EGb 761治疗SSNHL可改善患者的听阈和血液流变学指标,抑制炎症反应,促进听力功能的恢复。此外,未发现严重不良反应,具有足够的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Hemorheology of Ginkgo biloba Extract (EGb 761) in the Treatment of Sudden Sensorineural Hearing Loss: A Retrospective Study.

Objective: This study aimed to analyze the therapeutic effect of Ginkgo biloba extract (EGb 761) on sudden sensorineural hearing loss (SSNHL) and its influence on hemorheology.

Methods: The clinical data of patients diagnosed with SSNHL and admitted to the Wendeng Hospital of Traditional Chinese Orthopedics and Traumatology of Shandong Province from May 2020 to May 2023 were retrospectively analyzed. Based on different clinical treatment protocols, patients were divided into a control group (treated with routine treatment) and an administration group (treated with routine treatment + EGb 761). Both groups underwent drug treatment for 10 days. Subsequently, the hearing threshold, hemorheological parameters (blood high shear viscosity, blood low shear viscosity, plasma viscosity, and platelet aggregation rate) and inflammatory factors and serum levels (C-reactive protein, interleukin-6, tumor necrosis factor-α and soluble vascular cell adhesion molecule-1) of these groups were compared.

Results: This study comprised 120 patients, with 66 cases in the control group and 54 cases in the administration group. Following treatment, the total effective rate of the administration group was significantly higher than that of the control group (90.74% vs. 72.73%) (P-value < 0.05). The hearing threshold, hemorheological parameters, inflammatory factors, and serum levels were significantly lower in the administration group than in the control group (P-value < 0.05).

Conclusions: Compared with routine treatment, joint EGb 761 in the SSNHL treatment may improve the hearing threshold and hemorheological indexes of patients, inhibit the inflammatory response, and promote the recovery of hearing function. Moreover, no serious adverse reactions are observed, indicating adequate safety.

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来源期刊
Noise & Health
Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
CiteScore
2.10
自引率
14.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.
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