利用化学修饰纳米复合材料对实验动物大网膜模型的动脉粥样硬化产生积极影响的概念原理。

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Shamil Akhmedov PhD, MD , Ivan Stepanov MD , Sergey Afanasyev PhD, MD , Sergei Tverdokhlebov PhD , Victor Filimonov PhD , Nikolay Kamenshchikov MD , Anatoly Yermakov PhD , Suowen Xu PhD , Natalia Afanasyeva MD , Boris Kozlov PhD, MD
{"title":"利用化学修饰纳米复合材料对实验动物大网膜模型的动脉粥样硬化产生积极影响的概念原理。","authors":"Shamil Akhmedov PhD, MD ,&nbsp;Ivan Stepanov MD ,&nbsp;Sergey Afanasyev PhD, MD ,&nbsp;Sergei Tverdokhlebov PhD ,&nbsp;Victor Filimonov PhD ,&nbsp;Nikolay Kamenshchikov MD ,&nbsp;Anatoly Yermakov PhD ,&nbsp;Suowen Xu PhD ,&nbsp;Natalia Afanasyeva MD ,&nbsp;Boris Kozlov PhD, MD","doi":"10.1016/j.nano.2024.102787","DOIUrl":null,"url":null,"abstract":"<div><div>The use of chemically modified nanocomposites for atherosclerotic plaques can open up new opportunities for studying their effect on changing the structure of the plaque itself. It was shown on the model of the greater omentum of two groups of experimental animals (rats n = 30), which were implanted with Fe@C NPs nanocomposites of 10–30 Nm size into the omentum area. Group 1 (n = 15) consisted of animals that were implanted with chemically modified Fe@C NPs nanocomposites and control group 2 (n = 15) was with non-modified Fe@C NPs nanocomposites. After 1, 2 and 3 weeks we conducted the morphological study of changes in the structure of the omentum using two dyes (Nile Blue and Sudan III), which are specific for adipose tissue. Chemically modified nanocomposites have demonstrated, in contrast to non-modified nanoparticles, to cause morphological changes in the structure of the greater omentum accompanied by the probable release of a similar antiatherogenic factor.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"62 ","pages":"Article 102787"},"PeriodicalIF":4.2000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals\",\"authors\":\"Shamil Akhmedov PhD, MD ,&nbsp;Ivan Stepanov MD ,&nbsp;Sergey Afanasyev PhD, MD ,&nbsp;Sergei Tverdokhlebov PhD ,&nbsp;Victor Filimonov PhD ,&nbsp;Nikolay Kamenshchikov MD ,&nbsp;Anatoly Yermakov PhD ,&nbsp;Suowen Xu PhD ,&nbsp;Natalia Afanasyeva MD ,&nbsp;Boris Kozlov PhD, MD\",\"doi\":\"10.1016/j.nano.2024.102787\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The use of chemically modified nanocomposites for atherosclerotic plaques can open up new opportunities for studying their effect on changing the structure of the plaque itself. It was shown on the model of the greater omentum of two groups of experimental animals (rats n = 30), which were implanted with Fe@C NPs nanocomposites of 10–30 Nm size into the omentum area. Group 1 (n = 15) consisted of animals that were implanted with chemically modified Fe@C NPs nanocomposites and control group 2 (n = 15) was with non-modified Fe@C NPs nanocomposites. After 1, 2 and 3 weeks we conducted the morphological study of changes in the structure of the omentum using two dyes (Nile Blue and Sudan III), which are specific for adipose tissue. Chemically modified nanocomposites have demonstrated, in contrast to non-modified nanoparticles, to cause morphological changes in the structure of the greater omentum accompanied by the probable release of a similar antiatherogenic factor.</div></div>\",\"PeriodicalId\":19050,\"journal\":{\"name\":\"Nanomedicine : nanotechnology, biology, and medicine\",\"volume\":\"62 \",\"pages\":\"Article 102787\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine : nanotechnology, biology, and medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S154996342400056X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine : nanotechnology, biology, and medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S154996342400056X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

摘要

将化学修饰纳米复合材料用于动脉粥样硬化斑块可为研究其对改变斑块本身结构的影响提供新的机会。实验显示,在两组实验动物(大鼠,n = 30)的大网膜模型中,将尺寸为 10-30 Nm 的 Fe@C NPs 纳米复合材料植入大网膜区域。第 1 组(n = 15)的动物被植入化学改性的 Fe@C 纳米复合材料,第 2 组(n = 15)的动物被植入非改性的 Fe@C 纳米复合材料。1周、2周和3周后,我们使用两种针对脂肪组织的染料(尼罗蓝和苏丹Ⅲ)对网膜结构的变化进行了形态学研究。与未经改性的纳米颗粒相比,经化学改性的纳米复合材料已被证明可引起大网膜结构的形态学变化,并可能释放出类似的抗动脉粥样硬化因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals

Conceptual rationale for the use of chemically modified nanocomposites for active influence on atherosclerosis using the greater omentum model of experimental animals
The use of chemically modified nanocomposites for atherosclerotic plaques can open up new opportunities for studying their effect on changing the structure of the plaque itself. It was shown on the model of the greater omentum of two groups of experimental animals (rats n = 30), which were implanted with Fe@C NPs nanocomposites of 10–30 Nm size into the omentum area. Group 1 (n = 15) consisted of animals that were implanted with chemically modified Fe@C NPs nanocomposites and control group 2 (n = 15) was with non-modified Fe@C NPs nanocomposites. After 1, 2 and 3 weeks we conducted the morphological study of changes in the structure of the omentum using two dyes (Nile Blue and Sudan III), which are specific for adipose tissue. Chemically modified nanocomposites have demonstrated, in contrast to non-modified nanoparticles, to cause morphological changes in the structure of the greater omentum accompanied by the probable release of a similar antiatherogenic factor.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信