从 Chrysanthemum morifolium cv. Fubaiju 的头状花序中提取的两种新化合物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-10-01 DOI:10.1080/14786419.2024.2409981

Jin-Lin Chen, Yue-Hao Huang, Si-Yu Yang, Xue-Fang Zhuo, Yao-Lan Li, Yu-Bo Zhang, Jun-Jie Zhong, Guo-Cai Wang

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引用次数: 0

摘要

从菊花（Chrysanthemum morifolium cv. Fubaiju）的头状花序中分离出了一种新的胚芽萜类化合物（1）和一种新的烷酰胺类化合物（2），以及六种已知化合物（3-8）。通过综合光谱分析和量子化学计算，阐明了这些新化合物的结构。通过一维核磁共振数据与现有文献数据进行比较，确定了已知结构的特征。在分离物中，化合物 5 对人肺癌 A549 细胞和人肝癌 HepG2 细胞具有抑制活性，IC50 值分别为 19.50 ± 1.23 µM 和 23.24 ± 1.30 µM；化合物 8 对 RSV 感染具有抑制作用，IC50 值为 12.50 ± 1.02 µM。

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Two new compounds from the capitula of Chrysanthemum morifolium cv. Fubaiju.

A new germacrane-type sesquiterpenoid (1) and a new alkamide (2), as well as six known compounds (3-8) were isolated from the capitula of Chrysanthemum morifolium cv. Fubaiju. The new structures were elucidated by comprehensive spectroscopic analysis and quantum chemical calculations. The known structures were characterised via 1D NMR data compared with the already existing literature data. Among the isolates, compound 5 showed inhibitory activity against human lung cancer A549 cells and human hepatoma HepG2 cells with the IC₅₀ values of 19.50 ± 1.23 and 23.24 ± 1.30 µM, respectively, and compound 8 exhibited inhibitory effect on RSV infection with IC₅₀ value of 12.50 ± 1.02 µM.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.