Rodrigo Cunha Oliveira, Darren Martin, Juliana Sacramento Mota de Souza, Luiz Carlos Júnior Alcântara, Monick Lindenmeyer Guimarães, Carlos Brites, Joana Paixão Monteiro-Cunha
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引用次数: 0
摘要
背景：巴西的人类免疫缺陷病毒 1（HIV-1）感染主要由 B 和 C 两种亚型引起：在此，我们介绍了一种新型 HIV-1 重组形式的特征，它表明了一种新的巴西 CRF_BC，名为 CRF146_BC：方法：使用 RDP、JphMM 和 Simplot 重组工具评估马赛克模式：在这项工作中，我们发现了三个以前被归类为独特重组形式（URF）的 HIV-1 核苷酸序列，以及一个具有相同 BC 重组模式的新的部分基因组。在整合酶水平上，马赛克基因组几乎完全由 C 亚型序列代表，在 pol 基因中有一个小的 B 亚型重组区。系统发生学分析强烈表明，这些分离自南里约格朗德州、里约热内卢州和巴伊亚州的菌株具有共同的起源：因此，新的 HIV-1 CRF146_BC 在巴西三个不同地区流行：主要结论：因此，新的 HIV-1 CRF146_BC 在巴西三个不同地区流行：南部、东南部和东北部。
Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil.
Background: The human immunodeficiency virus 1 (HIV-1) infections in Brazil are predominantly caused by two subtypes, B and C.
Objectives: Here we present the characterisation of a novel HIV-1 recombinant form, indicating a new Brazilian CRF_BC, named CRF146_BC.
Methods: RDP, JphMM and Simplot recombination tools were used to evaluate the mosaic pattern.
Findings: In this work, we identified three HIV-1 nucleotide sequences previously classified as unique recombinant forms (URFs), plus one new partial genome sharing the same BC recombination pattern. The mosaic genome is almost entirely represented by the subtype C sequence, with a small subtype B recombination region in the pol gene, at the Integrase level. The phylogenetic analyses strongly indicate a common origin between the strains, which were isolated in Rio Grande do Sul, Rio de Janeiro and Bahia states.
Main conclusions: Thus, the new HIV-1 CRF146_BC is circulating in three different Brazilian regions: South, Southeast and Northeast.
期刊介绍：
Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study.
Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome.
It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.
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