意外死亡者一级亲属中自杀、意外死亡和主要精神障碍的家族聚集。

IF 6.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2024-10-01 DOI:10.1016/j.mayocp.2024.06.014

Mu-Hong Chen MD, PhD , Shih-Jen Tsai MD , Chih-Ming Cheng MD , Wen-Han Chang MS , Ya-Mei Bai MD, PhD , Tung-Ping Su MD , Tzeng-Ji Chen MD, PhD

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引用次数: 0

摘要

研究目的研究意外死亡者的一级亲属（FDRs）自杀、意外死亡和主要精神障碍的风险。有证据表明，冲动和冒险的内表型与家庭中的主要精神障碍、自杀和意外死亡有共同之处：本研究共纳入了 136 011 名意外死亡者的 FDR，以及 544 044 名年龄和性别匹配的对照组。研究评估了这两组人意外死亡和自杀的相对风险。研究还确定了各组间主要精神疾病（包括精神分裂症、双相情感障碍、重度抑郁障碍、自闭症谱系障碍和注意力缺陷多动障碍）发生频率的差异：与对照组相比，死于意外事故的 FDRs 更有可能死于意外事故（相对风险 [RR] = 4.62）和自杀（RR = 1.54）。与未死于意外事故者的FDR相比，死于意外事故者的FDR患精神分裂症（RR = 1.24）、双相情感障碍（RR = 1.18）、重度抑郁障碍（RR = 1.26）和注意缺陷多动障碍（RR = 1.10）的风险更高：我们的研究结果可以提醒公共卫生官员和临床医生密切关注意外死亡者的FDRs的精神健康状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Familial Coaggregation of Suicide, Accidental Death, and Major Psychiatric Disorders in First-Degree Relatives of Individuals Dying Accidentally

Objective

To investigate the risks of suicide, accidental death, and major psychiatric disorders in first-degree relatives (FDRs) of people who die accidentally. Evidence has shown that the endophenotypes of impulsivity and risk-taking are known to coaggregate with major psychiatric disorders, suicide, and accidental deaths within families.

Methods

In total, 136,011 FDRs of individuals who died from accidents and 544,044 individuals matched for age and sex who served as a control group were included in the present study. The relative risks of accidental death and suicide were assessed between these groups. Differences in the frequencies of major psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder (ADHD) between the groups were also identified.

Results

The FDRs of individuals who died from accidents were more likely to themselves die from accidents (relative risk [RR] = 4.62) and by suicide (RR = 1.54) compared with individuals in the control group. The FDRs of individuals who died from accidents had an increased risk of developing schizophrenia (RR = 1.24), bipolar disorder (RR = 1.18), major depressive disorder (RR = 1.26), and attention deficit hyperactivity disorder (RR = 1.10) compared with the FDRs of individuals who did not die from accidents.

Conclusion

Our findings may serve as a reminder to public health officials and clinicians to monitor closely the mental health of the FDRs of individuals who die from accidents.

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.