了解肝细胞癌血管的进展:对诊断、预后和治疗的影响》。

IF 4.4 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hyungjin Rhee, Young Nyun Park, Jin-Young Choi
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引用次数: 0

摘要

肝细胞癌(HCC)会经历多个肝癌发生阶段,每个阶段都会出现血管供应、引流和微血管结构的特定变化。这些血管变化会对 HCC 的成像结果产生重大影响,从而实现无创诊断。HCC 的血管变化与侵袭性组织学特征和治疗反应密切相关。肿瘤向周围肝脏门静脉的静脉引流促进了血管入侵,而包裹肿瘤簇的独特微血管模式(称为 VETC 模式)促进了血管入侵和转移。目前越来越多的 HCC 系统治疗方法主要针对血管生成和免疫检查点通路,而这两种通路密切相关。通过了解肝癌发生过程中组织病理学血管变化之间的复杂关系及其对成像结果的影响,放射科医生可以提高成像诊断的准确性,改善对预后和治疗反应的预测。这反过来又将最终带来更好的患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in Understanding Hepatocellular Carcinoma Vasculature: Implications for Diagnosis, Prognostication, and Treatment.

Hepatocellular carcinoma (HCC) progresses through multiple stages of hepatocarcinogenesis, with each stage characterized by specific changes in vascular supply, drainage, and microvascular structure. These vascular changes significantly influence the imaging findings of HCC, enabling non-invasive diagnosis. Vascular changes in HCC are closely related to aggressive histological characteristics and treatment responses. Venous drainage from the tumor toward the portal vein in the surrounding liver facilitates vascular invasion, and the unique microvascular pattern of vessels that encapsulate the tumor cluster (known as a VETC pattern) promotes vascular invasion and metastasis. Systemic treatments for HCC, which are increasingly being used, primarily target angiogenesis and immune checkpoint pathways, which are closely intertwined. By understanding the complex relationship between histopathological vascular changes in hepatocarcinogenesis and their implications for imaging findings, radiologists can enhance the accuracy of imaging diagnosis and improve the prediction of prognosis and treatment response. This, in turn, will ultimately lead to better patient care.

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来源期刊
Korean Journal of Radiology
Korean Journal of Radiology 医学-核医学
CiteScore
10.60
自引率
12.50%
发文量
141
审稿时长
1.3 months
期刊介绍: The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.
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