大鼠肾小球滤过过程中滤过狭缝中产生的剪切应力力的数值流动模拟

IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Alexander Fuhrmann, Balazs Pritz, Karlhans Endlich, Wilhelm Kriz
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引用次数: 0

摘要

背景:人们对肾小球滤过过程中挑战荚膜细胞固定到 GBM 的流动动力了解不足:方法:使用数值流动模拟来估算大鼠肾脏中的这些力。根据罗德瓦尔德(Rodewald)和卡尔诺夫斯基(Karnovsky)1 的观点,模拟运行的裂隙隔膜三维模型为拉链结构。GBM 被模拟为多孔介质:结果:滤液流产生的平均壁剪应力为 39 Pa,脚过程的质膜上的最大剪应力为 152 Pa,裂隙隔膜内表面的最大剪应力为 250 Pa。裂隙隔膜占肾小球滤过屏障流体动力阻力的 25%。根据三维模型的结果,我们开发了一个二维模型,可以进行大量的参数变化。将滤过狭缝宽度从 40 纳米减少到 30 纳米几乎使壁剪应力增加了一倍。此外,将滤液流速提高 50%,壁面剪切应力也增加了 47%。当增加狭缝隔膜的粘滞阻力时,穿过狭缝隔膜的压降增加到难以容忍的高值。狭缝隔膜的粘滞阻力低于 GBM 的粘滞阻力,导致压力沿过滤屏障逐渐下降。在过滤表面的限定区域,结节细胞下空间缓解了这些挑战,但对总体压力的影响微乎其微:结论:滤过屏障承受着高水平的剪切力和压力应力,这是许多肾小球疾病的特征之一,也是受伤但存活的荚膜细胞从 GBM 上脱落的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Numerical Flow Simulations of the Shear Stress Forces Arising in Filtration Slits during Glomerular Filtration in Rat Kidney.
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来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
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