中央浆液性脉络膜视网膜病变的风险因素与血管内皮生长因子、hs-CRP 和 ESR。

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI:10.1155/2024/9322594
Lingjuan Sun, Li Yin, Shurui Wang, Haiyan Wang
{"title":"中央浆液性脉络膜视网膜病变的风险因素与血管内皮生长因子、hs-CRP 和 ESR。","authors":"Lingjuan Sun, Li Yin, Shurui Wang, Haiyan Wang","doi":"10.1155/2024/9322594","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.</p><p><strong>Methods: </strong>A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.</p><p><strong>Results: </strong>The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, <i>Helicobacter pylori</i> infection, steroid use, and shift work compared to the control group (<i>P</i> < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group (<i>P</i> < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group (<i>P</i> < 0.05). Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC (<i>P</i> < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.</p>","PeriodicalId":16674,"journal":{"name":"Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427725/pdf/","citationCount":"0","resultStr":"{\"title\":\"Risk Factors and VEGF, hs-CRP, and ESR in Central Serous Chorioretinopathy.\",\"authors\":\"Lingjuan Sun, Li Yin, Shurui Wang, Haiyan Wang\",\"doi\":\"10.1155/2024/9322594\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.</p><p><strong>Methods: </strong>A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.</p><p><strong>Results: </strong>The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, <i>Helicobacter pylori</i> infection, steroid use, and shift work compared to the control group (<i>P</i> < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group (<i>P</i> < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group (<i>P</i> < 0.05). Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC (<i>P</i> < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Male gender, shift work, <i>Helicobacter pylori</i> infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.</p>\",\"PeriodicalId\":16674,\"journal\":{\"name\":\"Journal of Ophthalmology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427725/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/9322594\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2024/9322594","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

研究目的本研究旨在探讨中心性浆液性脉络膜视网膜病变(CSC)的相关危险因素,并分析血管内皮生长因子(VEGF)、高敏C反应蛋白(hs-CRP)、红细胞沉降率(ESR)与CSC的关系:共纳入2017年2月至2021年2月在我院眼科门诊确诊为CSC的109例患者(CSC组),103例来自我院体检中心的志愿者作为对照组。此外,新的多模态成像分类将109例CSC患者进一步分为简单CSC(57例)和复杂CSC(52例)。研究人员收集了患者的人口统计学数据、基础疾病、病史和用药史。测量血管内皮生长因子、hs-CRP和血沉的水平,并进行多因素逻辑回归分析,以确定影响CSC的因素。结果显示,CSC 组患者的血管内皮生长因子、hs-CRP 和血沉的比例较高:结果:与对照组相比,CSC 组男性、吸烟史、饮酒、合并阻塞性睡眠呼吸暂停、甲状腺功能减退、肾脏疾病、幽门螺杆菌感染、使用类固醇和轮班工作的比例更高(P < 0.05)。CSC 组的血管内皮生长因子、hs-CRP 和 ESR 水平明显高于对照组(P < 0.05)。复杂 CSC 组的血管内皮生长因子、hs-CRP 和 ESR 水平高于简单 CSC 组(P < 0.05)。男性性别、轮班工作、幽门螺杆菌感染、甲状腺功能减退、血管内皮生长因子、hs-CRP 和 ESR 升高被认为是 CSC 的危险因素(P < 0.05)。VEGF、hs-CRP和ESR的综合诊断价值(ROC曲线下面积:0.886)高于单个标记物的诊断价值(分别为0.722、0.728和0.703)(P<0.05):男性性别、轮班工作、幽门螺杆菌感染、甲状腺功能减退以及血管内皮生长因子、hs-CRP 和 ESR 水平升高是 CSC 的危险因素。联合使用血管内皮生长因子、hs-CRP和血沉可提高识别CSC的诊断效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk Factors and VEGF, hs-CRP, and ESR in Central Serous Chorioretinopathy.

Objective: This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.

Methods: A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.

Results: The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, Helicobacter pylori infection, steroid use, and shift work compared to the control group (P < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group (P < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group (P < 0.05). Male gender, shift work, Helicobacter pylori infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC (P < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) (P < 0.05).

Conclusion: Male gender, shift work, Helicobacter pylori infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信