快讯对乙酰氨基酚与脓毒症相关急性肾损伤患者死亡风险之间的关系:来自 MIMIC-IV 数据库的回顾性队列研究。

IF 2.5 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Journal of Investigative Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI:10.1177/10815589241290210
Hui Yu, Ting Yang, Dongsong Liu
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引用次数: 0

摘要

脓毒症相关急性肾损伤(SA-AKI)的发生预示着较差的预后。我们旨在评估对乙酰氨基酚的使用对SA-AKI患者短期死亡率的影响。这项回顾性队列研究共纳入了 2008-2019 年重症监护医学信息市场 IV(MIMIC-IV)数据库中的 6563 名确诊为 SA-AKI 的患者。研究采用 Cox 回归模型分析对乙酰氨基酚与 30 天死亡率和住院死亡率的关系。此外,还对使用对乙酰氨基酚与未使用对乙酰氨基酚的患者进行了倾向评分匹配(PSM)分析。在这些患者中,1421 名患者(21.65%)出现了 30 天死亡,1246 名患者(18.99%)出现了院内死亡。使用对乙酰氨基酚的患者 30 天死亡风险降低[危险比 (HR)=0.80, 95% 置信区间 (CI): 0.71-0.90],院内死亡风险降低(HR=0.72, 95%CI: 0.63-0.82)。PSM 分析表明,使用对乙酰氨基酚仍与降低 30 天死亡率和住院死亡率风险有关。亚组分析表明,对乙酰氨基酚与 30 天死亡率和住院死亡率之间的关系在不同亚组中是一致的(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between acetaminophen and risk of mortality in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database.

The occurrence of sepsis-associated acute kidney injury (SA-AKI) predicts a worse prognosis. We aimed to assess the impact of acetaminophen use on short-term mortality in patients with SA-AKI. A total of 6563 patients diagnosed with SA-AKI from the 2008 to 2019 Medical Information Mart for Intensive Care IV (MIMIC-IV) database were enrolled in this retrospective cohort study. The Cox regression model was utilized to analyze the associations of acetaminophen with 30-day mortality and in-hospital mortality. Additional propensity score matching (PSM) analysis was performed regarding patients with acetaminophen use versus those without. Of these patients, 30-day mortality occurred in 1421 (21.65%) patients and in-hospital mortality in 1246 (18.99%) patients. Patients who used acetaminophen were associated with a reduced risk of 30-day mortality (hazard ratio (HR) = 0.80, 95% confidence interval (CI): 0.71-0.90) and in-hospital mortality (HR = 0.72, 95% CI: 0.63-0.82). The PSM analysis demonstrated that acetaminophen use was still related to a reduced risk of 30-day mortality and in-hospital mortality. Subgroup analysis showed that the relationships between acetaminophen and 30-day mortality and in-hospital mortality were consistent across subgroups (p < 0.05). The use of acetaminophen has an association with lower short-term mortality in patients with SA-AKI.

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来源期刊
Journal of Investigative Medicine
Journal of Investigative Medicine 医学-医学:内科
CiteScore
4.90
自引率
0.00%
发文量
111
审稿时长
24 months
期刊介绍: Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research. JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.
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