利用内窥镜超声引导下采集的组织样本，研究不可切除胰腺癌患者肿瘤 CD8 表达与临床病程的相关性。

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-09-27 DOI:10.1002/jhbp.12072

Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Ryuichi Watanabe, Ryo Sato, Masanori Yasuda

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引用次数: 0

摘要

研究背景本研究旨在利用内镜超声引导下组织采集（EUS-TA）获得的组织样本，评估不可切除的胰腺导管腺癌（PDAC）患者肿瘤CD8表达与临床病程之间的相关性：纳入2017年9月至2021年10月期间接受EUS-TA治疗前的不可切除PDAC患者。对 CD8 阳性区域的定位进行定性评估。我们根据 CD8 阳性区域的中位百分比将患者分为高组和低组。评估了 CD8 阳性区域数量与总生存期之间的相关性。此外，还评估了接受化疗的患者对化疗的反应：共有169名患者纳入分析。中位总生存期为171天（95%置信区间[CI]：86-401）。CD8 阳性面积中位数为 0.10%（95% 置信区间：0.05-0.26）。CD8阳性率高（≥0.1%）和低（结论：CD8阳性率低）的中位总生存率分别为0.5%和0.5%：使用 EUS-TA 采集的不可切除 PDAC 患者组织样本显示，CD8 表达不会影响患者的临床病程。

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The correlation between tumoral CD8 expression and clinical course in patients with unresectable pancreatic cancer using tissue samples acquired by endoscopic ultrasound-guided tissue acquisition.

Background: The aim of this study was to evaluate the correlation between tumoral CD8 expression and the clinical course in patients with unresectable pancreatic ductal adenocarcinoma (PDAC) using tissue samples acquired by endoscopic ultrasound-guided tissue acquisition (EUS-TA).

Methods: Patients with unresectable PDAC who underwent EUS-TA prior to treatment between September 2017 and October 2021 were included. The localization of the CD8-positive areas was qualitatively evaluated. We divided the patients into high and low groups based on the median percentage of CD8-positive areas. The correlation between the number of CD8-positive areas and overall survival was assessed. Furthermore, the response to chemotherapy was assessed in patients who underwent chemotherapy.

Results: A total of 169 patients were included in the analysis. The median overall survival was 171 days (95% confidence interval [CI]: 86-401). The median CD8-positive area was 0.10% (95% CI: 0.05-0.26). The median overall survival in the high (≥0.1%) and low (<0.1%) CD8-positive groups were 156 and 213.5 days, respectively (p = .33). The number of CD8-positive areas was not correlated with the overall survival and response to chemotherapy (p = .69).

Conclusions: Tissue samples acquired using EUS-TA from patients with unresectable PDAC showed that CD8 expression did not affect the clinical course of patients.

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来源期刊

Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY

自引率

10.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.