这是一台用途广泛的分子机器。

IF 2.7 3区生物学 Q3 MICROBIOLOGY

Journal of Bacteriology Pub Date : 2024-10-24 Epub Date: 2024-09-30 DOI:10.1128/jb.00351-24

Michael D Manson

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引用次数: 0

摘要

在本期（J Bacteriol. 206: e0014024, https://doi.org/10.1128/jb.00140-24）中，Ridone 和 Baker 描述了两种 5:2 异七聚体离子动力马达之间的杂交。他们在细菌鞭毛的定子单元和 Ton 外膜运输系统的 ExbBD 之间构建了嵌合体。14 个杂交体中只有一个支持在大肠杆菌中游动。在远离杂交区域的位点上的另外三个残基变化增强了运动能力。这项工作表明，鞭毛定子单元和 ExbBD 有一个共同的祖先，在进化过程中发生了分化，以执行不同的任务。

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A very versatile molecular machine.

In this issue (J Bacteriol. 206: e0014024, https://doi.org/10.1128/jb.00140-24), Ridone and Baker describe hybrids between two 5:2 heteroheptameric ion-powered motors. Chimeras were constructed between stator units of a bacterial flagellum and ExbBD of the Ton outer-membrane transport system. Only one of the 14 hybrids supported swimming in Escherichia coli. Three additional residue changes at sites distant from the hybrid region enhanced motility. This work suggests that flagellar stator units and ExbBD share an ancestor that diverged during evolution to perform different tasks.

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来源期刊

Journal of Bacteriology 生物-微生物学

CiteScore

6.10

自引率

9.40%

发文量

324

审稿时长

1.3 months

期刊介绍： The Journal of Bacteriology (JB) publishes research articles that probe fundamental processes in bacteria, archaea and their viruses, and the molecular mechanisms by which they interact with each other and with their hosts and their environments.