使用赛拉嗪和行为改变的个人经历:对 Reddit 帖子的定性内容分析。

IF 4.2 3区 医学 Q1 SUBSTANCE ABUSE
Omeid Heidari, Olivia K Sugarman, Abigail K Winiker, Sabrina Gattine, Vivian Flanagan, Roham Razaghi, Brendan K Saloner
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引用次数: 0

摘要

目的:在美国的药品供应中,异丙嗪是一种迅速蔓延的掺杂物,越来越多地与用药过量和严重伤口有关,但有关人体接触异丙嗪后的临床表现或治疗方法的信息却十分匮乏。本研究旨在探究那些报告使用过毒品并向社交媒体网站 Reddit 投稿的人对毒品供应中的异丙嗪的个人态度以及与异丙嗪相关的使用经历:为了进行回顾性定性内容分析,研究小组从 Reddit 上提取了所有提及 "xylazine "或 "tranq "的帖子和评论。研究小组从 10 个 Reddit 论坛或子论坛中提取了与药物使用相关的内容,其中包括在提取日期(2023 年 1 月)或之前创建的内容。总共确定了 3284 篇帖子,并采用归纳法对其中的 1803 篇进行了定性编码,直到达到意义饱和为止:评论和帖子中出现了三个主题:(1) 使用异丙嗪的个人经历,包括对过量、戒断和伤口的负面影响;(2) 针对毒品供应中异丙嗪的行为变化,包括设计和分享新的减少危害和检测技巧,以及减少或完全戒断毒品使用;(3) 认为缺乏治疗异丙嗪戒断的选择,以及分享信息以帮助他人自我治疗戒断症状,最常见的是使用氯硝安定:这项针对使用过二甲肼毒品的人进行的研究为人们如何看待二甲肼、可能的治疗方式以及潜在的临床研究方法提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Personal Experiences With Xylazine and Behavior Change: A Qualitative Content Analysis of Reddit Posts.

Objectives: Xylazine is a rapidly spreading adulterant in the United States' drug supply and is increasingly associated with overdoses and severe wounds, but there is a dearth of information about the clinical presentation or means of treatment for human xylazine exposure. The objective of this study was to explore personal attitudes about xylazine in the drug supply and experiences with xylazine-related use among people who reported using drugs and contributed content to social media site Reddit.

Methods: To conduct a retrospective qualitative content analysis, the study team extracted all posts and comments from Reddit, which mentioned the terms "xylazine" or "tranq." Content was extracted from 10 Reddit forums, or subreddits, specific to drug use, and included content created on or before the extraction date of January 2023. In total, 3284 posts were identified and 1803 were qualitatively coded using an inductive approach until meaning saturation was reached.

Results: Three themes emerged across comments and posts: (1) personal experiences with xylazine, including a negative impact on overdose, withdrawal, and wounds; (2) behavior changes in response to xylazine in the drug supply, including devising and sharing new harm reduction and detection tips, and reducing or abstaining from drug use altogether; (3) a perceived lack of treatment options for xylazine withdrawal and information sharing to help others self-treat withdrawal symptoms, most often with clonidine.

Conclusions: This study of people who reported using drugs with xylazine provides new insights into how xylazine is perceived, possible treatment modalities, and potential clinical research approaches.

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来源期刊
Journal of Addiction Medicine
Journal of Addiction Medicine 医学-药物滥用
CiteScore
6.10
自引率
9.10%
发文量
260
审稿时长
>12 weeks
期刊介绍: The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.
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