植物提取物和欧米伽-3补充剂可调节海马氧脂素对LPS诱导的神经炎症的反应。

IF 4.8 3区 医学 Q2 CELL BIOLOGY
Inflammation Research Pub Date : 2024-11-01 Epub Date: 2024-09-28 DOI:10.1007/s00011-024-01947-9
Marie Martin, Emie Debenay, Jeanne Bardinet, Adrien Peltier, Line Pourtau, David Gaudout, Sophie Layé, Véronique Pallet, Anne-Laure Dinel, Corinne Joffre
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引用次数: 0

摘要

目的和设计:神经炎症是一种保护机制,但如果长期和/或不加以调节,就会变得有害,导致神经元损伤和认知改变。葡萄和蓝莓多酚、藏红花类胡萝卜素和欧米茄-3等营养素具有抗炎和促进恢复的特性,可以限制炎症并促进炎症的缓解:本研究探讨了 149 只小鼠在脂多糖(LPS,250 微克/千克)诱发神经炎症后不同时间点(30 分钟、2 小时、6 小时)补充植物提取物(葡萄、蓝莓和藏红花)、ω-3 或两者(混合)18 天对神经炎症的影响。对每个时间点的炎症、氧化和神经保护基因表达、氧化脂蛋白定量和脂肪酸组成进行了分析。对所有这些生物标记物进行了 PCA 分析:结果:混合营养素的补充引起了炎症缓解的变化。事实上,与 LPS 组相比,补充组海马中促炎介质的产生开始得更早。在补充营养的小鼠体内还发现了更多的促消炎介质。这些变化与 LPS 后 6 小时海马抗氧化状态的增加有关:这些研究结果表明,使用植物提取物和欧米加-3进行膳食干预有助于预防神经炎症,从而预防与年龄相关的认知能力衰退。还需要进一步研究这些补充剂对衰老背景下慢性炎症的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation.

Objective and design: Neuroinflammation is a protective mechanism but can become harmful if chronic and/or unregulated, leading to neuronal damage and cognitive alterations. Limiting inflammation and promoting resolution could be achieved with nutrients such as grapes and blueberries polyphenols, saffron carotenoids, and omega-3, which have anti-inflammatory and proresolutive properties.

Methods: This study explored the impact of 18-day supplementation with plant extracts (grape, blueberry and saffron), omega-3 or both (mix) on neuroinflammation induced by lipopolysaccharide (LPS, 250 µg/kg) in 149 mice at different time points post-LPS treatment (30 min, 2 h, 6 h). Inflammatory, oxidative and neuroprotective gene expression; oxylipin quantification; and fatty acid composition were analyzed at each time point. PCA analysis was performed with all these biomarkers.

Results: Mix supplementation induced changes in the resolution of inflammation. In fact, the production of proinflammatory mediators in the hippocampus started earlier in the supplemented group than in the LPS group. Pro-resolving mediators were also found in higher quantities in supplemented mice. These changes were associated with increased hippocampal antioxidant status at 6 h post-LPS.

Conclusions: These findings suggest that such dietary interventions with plant extracts, and omega-3 could be beneficial in preventing neuroinflammation and, consequently, age-related cognitive decline. Further research is needed to explore the effects of these supplements on chronic inflammation in the context of aging.

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来源期刊
Inflammation Research
Inflammation Research 医学-免疫学
CiteScore
9.90
自引率
1.50%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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