白癜风发病机制中的翻译后修饰。

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunologic Research Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI:10.1007/s12026-024-09545-x

Lu Lu, Huimin He, Jindi Feng, Zhonghui Hu, Shiyu Zhang, Lu Yang, Yuehua Liu, Tao Wang

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引用次数: 0

摘要

白癜风是一种以皮肤色素脱失为特征的慢性皮肤病。其病因复杂，涉及多种因素，尚未完全阐明。蛋白质翻译后修饰途径已被证明在炎症性皮肤病中起着重要作用，但对白癜风的研究仍然有限。本综述将重点讨论翻译后修饰在白癜风发病机制中的作用，尤其是它们对与免疫反应和黑素细胞存活相关的细胞信号通路的影响。文章讨论了目前针对这些通路的治疗策略，强调了新型疗法在白癜风治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Post-translational modification in the pathogenesis of vitiligo.

Vitiligo is a chronic dermatological condition marked by the loss of skin pigmentation. Its complex etiology involves multiple factors and has not been completely elucidated. Protein post-translational modification pathways have been proven to play a significant role in inflammatory skin diseases, yet research in the context of vitiligo remains limited. This review focuses on the role of post-translational modifications in vitiligo pathogenesis, especially their impact on cellular signaling pathways related to immune response and melanocyte survival. Current therapeutic strategies targeting these pathways are discussed, emphasizing the potential for novel treatments in vitiligo management.

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来源期刊

Immunologic Research 医学-免疫学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.