高血压患者右心室纵向应变与不良预后之间的关系:10年随访

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE
Marijana Tadic, Jelena Suzic, Aleksandra Sljivic, Anita Andric, Vladan Vukomanovic, Tamara Filipovic, Vera Celic, Cesare Cuspidi
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引用次数: 0

摘要

导言:以往的研究表明,右心室重塑对动脉性高血压患者非常重要,而右心室纵向应变被认为是检测细微心脏损害的非常敏感的参数。目的:本研究旨在评估在平均随访 10 年的大型高血压患者群体中,RV 纵向应变(整体和自由壁)与 MACE 测量的不良后果之间的关系:这项回顾性研究最终纳入了2010年1月至2014年12月期间接受包括二维斑点追踪成像在内的全面超声心动图检查的544名高血压患者。随访期间,MACE 被视为主要结果,其定义为全因死亡率、心血管死亡率、心肌梗死、冠状动脉旁路、冠状动脉支架植入、中风、心力衰竭和心房颤动:发生MACE的患者年龄大于未发生MACE的患者。MACE和非MACE患者的人口统计学和临床参数没有差异。心室直径没有差异,但MACE患者的心室壁厚度较高。两组患者的 RV 收缩功能参数相似。在对最初无并发症的高血压患者进行的10年随访中,RV GLS和RV自由壁纵向应变与不良预后有独立关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Relationship Between Right Ventricular Longitudinal Strain and Adverse Outcome in Hypertensive Patients: 10-year Follow-up.

Introduction: Previous studies showed the importance of right ventricular (RV) remodeling in patients with arterial hypertension and RV longitudinal strain was recognized as very sensitive parameter for detection of subtle cardiac impairment. However, its clinical importance in arterial hypertension has not been established so far.

Aim: The present study aimed to evaluate the association between RV longitudinal strain (global and free-wall) on adverse outcomes measured by MACE in the large group of hypertensive patients who were followed for mean period of 10 years.

Methods: This retrospective study finally included 544 hypertensive patients who underwent full echocardiographic examination including 2D speckle tracking imaging. between January 2010 and December 2014. MACE was considered as the primary outcome and it was defined by all-cause mortality, cardiovascular mortality, myocardial infarction, coronary artery by-pass, coronary stent implantation, stroke, development of heart failure, and occurrence of atrial fibrillation during follow-up.

Results: Patients who experienced MACE were older than those who did not. There was no difference in demographic and clinical parameters between MACE and non-MACE patients. There was no difference in RV diameter, but MACE patients had higher RV wall thickness. RV systolic function parameters were similar between the two groups. RV global and free-wall longitudinal strain were significantly lower in MACE patients (-22.3 ± 3.6 vs. -24.7 ± 3.9%, p < 0.001 and - 25.8 ± 4.2 vs. -28.1 ± 4.5%, p < 0.001; respectively). Reduced RV GLS [OR 1.10; 95%: 1.02-1.20] and reduced RV free-wall longitudinal strain [OR 1,21; 95%CI: 1.05-1.39] were independently of clinical and echocardiographic parameters related with adverse outcome measured by MACE.

Conclusion: RV GLS and RV free-wall longitudinal strain were independently related with adverse outcomes during 10-year follow-up in initially uncomplicated hypertensive patients.

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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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