接受疼痛的神经相关性和小脑的作用:头痛患者与匹配对照组的功能连接和解剖学差异。

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY
Vasilis S Vasiliou, Nikos Konstantinou, Yiolanda Christou, Savvas Papacostas, Fofi Constantinidou, Eleni Heracleous, Ioannis Seimenis, Maria Karekla
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引用次数: 0

摘要

背景:尽管头痛患者中存在功能连接网络功能障碍,但还没有研究对头痛应对的功能连接神经相关性和解剖差异进行研究:尽管头痛患者存在功能连接网络功能障碍,但还没有研究对应对头痛的功能连接神经相关性和解剖学差异进行研究:本研究调查了37名原发性头痛患者和24名年龄与性别匹配的对照组患者全脑功能连接的个体间变异性和解剖学差异,以及心理灵活性(PF)的神经相关性,心理灵活性曾被认为有助于头痛的适应。参与者(84%为女性;中位头痛严重程度=4/10;中位年龄=43岁)接受了功能磁共振成像扫描并填写了调查问卷,在控制年龄、性别、教育程度和头部运动的情况下,对整体和子网脑区及其与心理灵活性成分的关系进行了研究:结果:不同组间的种子分析和基于体素的对比分析显示,参与疼痛矩阵和核心静息态网络的区域存在非典型功能连接。疼痛接受是唯一与小脑相关的 PF 成分(x、y、z:28、-72、-34,P-误发现率结论):小脑最近被认为与调节情绪和认知过程有关,它处理的信息与个人在练习接受疼痛时处理的信息相似。我们的研究结果首次证实了小脑的这种联系及其在疼痛接受中的作用。我们认为,疼痛接受可能是一种行为生物标记目标,可以调节头痛问题感知和大脑网络异常:本研究强调了新出现的行为生物标志物(如疼痛接受度)在头痛管理中的潜在用途及其在改变头痛体验中的作用。值得注意的是,小脑和其他已知脑痛网络的灰质重组可能表明,可以通过有针对性的行为干预来改变脑网络,从而帮助解码头痛中占主导地位的非可塑性机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural correlates of pain acceptance and the role of the cerebellum: Functional connectivity and anatomical differences in individuals with headaches versus matched controls.

Background: Despite functional connectivity network dysfunction among individuals with headaches, no studies have examined functional connectivity neural correlates and anatomical differences in coping with headaches.

Methods: This study investigated inter-individual variability in whole-brain functional connectivity and anatomical differences among 37 individuals with primary headaches and 24 age- and gender-matched controls, and neural correlates of psychological flexibility (PF) that was previously found to contribute to headache adjustment. Participants (84% women; M headache severity = 4/10; M age = 43 years) underwent functional magnetic resonance imaging scans and completed questionnaires to examine global and subnetwork brain areas, and their relations with PF components, controlling for age, gender, education, and head-motion.

Results: Seed and voxel-based contrast analyses between groups showed atypical functional connectivity of regions involved in pain matrix and core resting-state networks. Pain acceptance was the sole PF component that correlated with the cerebellum (x, y, z: 28, -72, -34, p-false discovery rate <0.001), where individuals with headaches showed higher grey matter density compared to controls.

Conclusions: The cerebellum, recently implicated in modulating emotional and cognitive processes, was indicated to process information resembling what individuals do when practicing pain acceptance. Our findings establish for the first time this connection of the cerebellum and its role in pain acceptance. We propose that pain acceptance might be a behavioural biomarker target that could modulate problematic headache perceptions and brain networks abnormalities.

Significance: This study highlights the potential use of emerging behavioural biomarkers in headache management, such as pain acceptance, and their role in modifying the headache experience. Notably, grey matter reorganization in the cerebellum and other known brain pain networks, could indicate brain networks that can be modified from targeted behavioural interventions to help decode the nociplastic mechanisms that predominates in headaches.

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来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
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