母乳作为新生儿治疗剂的非营养用途：大脑、肠道和免疫目标。

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2024-09-27 DOI:10.1016/j.earlhumdev.2024.106126

Rebecca Hoban , Krystle M. Perez , D. Taylor Hendrixson , Gregory C. Valentine , Katie M. Strobel

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引用次数: 0

摘要

人乳（HM）具有生物活性、干细胞、抗炎、抗微生物和营养成分，其复杂的环境可改善婴儿的短期和长期预后。鉴于这种出色的生物液体，人们正在临床前和临床研究中探索将母乳作为靶向治疗的非营养性利用。本文介绍了有关 HM 非营养性用于治疗新生儿神经、胃肠道和感染性病症的最新研究以及未来发展方向。

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Non-nutritional use of human milk as a therapeutic agent in neonates: Brain, gut, and immunologic targets

Human milk (HM) exposure improves short- and long-term outcomes for infants due to a complex milieu of bioactive, stem cell, anti-inflammatory, anti-microbial, and nutritive components. Given this remarkable biologic fluid, non-nutritional utilization of HM as a targeted therapeutic is being explored in pre-clinical and clinical studies. This article describes recent research pertinent to non-nutritional uses of HM for neurologic, gastrointestinal, and infectious pathologies in neonates, as well as future directions.

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.