1 型糖尿病患者的死亡率：来自印度 ICMR - 青年糖尿病登记中心的单一中心经验。

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-09-25 DOI:10.1016/j.diabres.2024.111868

S.V. Madhu , P. Shukla , T. Kaur , R.S. Dhaliwal

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引用次数: 0

摘要

导言：在全球范围内，青少年糖尿病发病率不断上升，并发症和死亡率也随之增加。本研究旨在调查在印度北部一家三级医院登记的青年糖尿病患者的死亡率和死亡原因：我们分析了 2006 年至 2019 年在德里大学医学院登记的 1088 名青年糖尿病患者的死亡率和死亡原因。死亡信息通过电话、家访或医院记录获得。根据 ICMR 调查问卷进行了口头尸检，并根据世界卫生组织 ICD-10/11 确定了死因：结果：在平均随访 6.4 年的 898 名青年 1 型糖尿病（T1D）患者中，有 105 人（11.6%）死亡。43%的死亡病例起病年龄在 15 岁或以下，75.6%的死亡病例 HbA1C > 10%。24.2%的患者在确诊后两年内死亡，53.6%的患者在确诊后三年内死亡。慢性肾病、感染和酮症酸中毒是最常见的原因：我们发现，在印度北部一家三甲医院接受治疗的青年 T1D 患者血糖控制不佳，死亡率较高。

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Mortality in type 1 diabetes mellitus: A single centre experience from the ICMR – Youth onset diabetes registry in India

Introduction

The prevalence of youth onset diabetes is rising globally along with a greater burden of complications and mortality in them. The current study was undertaken to examine the mortality and causes of death in patients with youth onset diabetes registered in a tertiary care hospital in North India.

Methods

We analyzed mortality and causes of death in 1088 patients with youth onset diabetes registered from 2006 to 2019 at University College of Medical Sciences, Delhi. Information of death was obtained telephonically or by home visit or from hospital records wherever available. Verbal autopsy according to ICMR questionnaire was performed and cause of death determined as per WHO ICD-10/11.

Results

Among 898 youth onset type 1 diabetes mellitus (T1D) patients who had a mean follow up of 6.4 years, 105 deaths (11.6 %) occurred. Forty three percent of deaths had diabetes onset at 15 years or below, and 75.6 % had HbA1C > 10 %. Deaths occurred in 24.2 % within 2 years and in 53.6 % within 3 years of diagnosis. Chronic Kidney disease, infections and ketoacidosis were the commonest causes.

Conclusion

We found poor glycaemic control and high mortality in people with youth onset T1D being treated at a tertiary care hospital in north India.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.