尼古丁对 RNFL 的急性影响:尼古丁口香糖和电子香烟等戒烟辅助工具的比较分析。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Mohammed Alhazmi, Wafa Alotaibi
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引用次数: 0

摘要

目的:比较尼古丁口香糖和电子香烟(vaping)两种给药方式,研究尼古丁摄入对健康年轻人视网膜神经纤维层(RNFL)厚度的直接影响:根据产品标签和规格,20 名参与者在摄入 4 毫克尼古丁后的基线、30 分钟和 60 分钟接受了视网膜神经纤维层厚度测量。测量采用光学相干断层扫描(OCT)(Topcon 3D OCT-1 Maestro 系统)。尼古丁通过尼古丁口香糖或烟雾剂输送:结果:尼古丁口香糖和吸食都会导致 RNFL 厚度出现统计学意义上的显著增加,两种方法之间没有明显差异。分析显示,面积、时间和就诊因素对 RNFL 分数有明显影响。按吸烟类型(烟草、吸食电子烟、双重)进行的分层显示,面积、时间和就诊因素对RNFL有明显影响,这些因素之间存在交互作用:结论:研究结果凸显了尼古丁摄入量对年轻健康吸烟者RNFL厚度的急性影响。研究人员和临床医生在评估 RNFL 厚度时应考虑近期尼古丁暴露,尤其是在吸烟后一小时内。观察到的重大影响值得进一步研究,尤其是在老年人或健康受损人群中,以改进不同人群的临床方案和诊断评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nicotine acute impact on RNFL: a comparative analysis of smoking cessation aids including nicotine gum and electronic cigarettes.

Purpose: To investigate the immediate impact of nicotine consumption on Retinal Nerve Fiber Layer (RNFL) thickness in healthy young individuals, comparing nicotine gum and electronic cigarette (vaping) as delivery methods.

Materials and methods: Twenty participants underwent RNFL measurements at baseline, 30, and 60 minutes after consuming 4 mg of nicotine, based on product labeling and specifications. Measurements were obtained using optical coherence tomography (OCT) (Topcon 3D OCT-1 Maestro System). Nicotine was delivered through either nicotine gum or vaping.

Results: Both nicotine gum and vaping led to a statistically significant increase in RNFL thickness, with no significant difference between the two methods. The analysis revealed that area, time, and visit factors significantly affected RNFL scores. Stratification by smoking type (tobacco, vaping, dual) demonstrated significant effects for area, time, and visit factors, with an interaction effect among these factors.

Conclusions: The findings highlight the acute impact of nicotine intake on RNFL thickness in young healthy smokers. Researchers and clinicians should account for recent nicotine exposure when evaluating RNFL thickness, particularly within the first hour post-smoking. The observed significant effects warrant further research, especially in older or health-compromised populations, to improve clinical protocols and diagnostic evaluations across different demographics.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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